文章摘要

铁调素在非小细胞肺癌组织和血清中的表达及其与临床病理特征的相关性

作者: 1毛旭华, 1汤俊明, 1乔国洪, 2陈姝颖, 3井昶雯
1 江苏大学附属宜兴市人民医院检验科,江苏 无锡 214200
2 江苏大学附属宜兴市人民医院病理科,江苏 无锡 214200
3 南京医科大学附属肿瘤医院,江苏省肿瘤防治研究所,江苏省肿瘤医院临床肿瘤实验中心,南京 210009
通讯: 井昶雯 Email: jcw223200@163.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.008
基金: 江苏省卫生和计划生育委员会科研项目, Z201602 无锡市卫生和计划生育委员会面上项目, MS201536

摘要

目的:检测非小细胞肺癌(non-small cell lung cancer,NSCLC)患者肿瘤组织及血清标本中铁调素的水平,并探讨两者与其临床病理特征之间的相关性。方法:免疫组织化学检测60例NSCLC标本中铁调素的表达,应用ELISA检测血清中铁调素的含量,统计两者与临床病理特征的相关性。结果:组织中铁调素表达及血清铁调素水平与NSCLC的年龄、性别、病理类型、分化程度以及是否有淋巴结转移无显著相关性,但均与肿瘤分期及是否有远处转移相关。组织中铁调素表达与血清中铁调素水平并无显著相关性。结论:组织和血清中铁调素水平与NSCLC肿瘤分期及是否有远处转移相关,具体机制需要进一步研究。
关键词: 非小细胞肺癌 铁调素 免疫组织化学 远处转移

Expression of hepcidin in tumor tissues and serum and its correlation with clinicopathological features of non-small cell lung cancer

Authors: 1MAO Xuhua, 1TANG Junming, 1QIAO Guohong, 2CHEN Shuying, 3JING Changwen
1 Department of Clinical Laboratory, Affiliated Yixing People’s Hospital, Jiangsu University, Wuxi Jiangsu 214200
2 南京医科大学附属肿瘤医院,江苏省肿瘤防治研究所,江苏省肿瘤医院临床肿瘤实验中心,南京 210009
3 Clinical Cancer Research Center, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Jiangsu Cancer Hospital, Nanjing 210009, China

CorrespondingAuthor: JING Changwen Email: jcw223200@163.com

DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.008

Abstract

Objective: To investigate the expression levels of hepcidin in tumor tissues and serum of non-small cell lung cancer, and study its relationship with the clinicopathological features. Methods: Immunohistochemistry was applied to detect hepcidin protein in 60 non-small cell lung cancer patients. The levels of hepcidin in serum were detected by ELISA. Results: Both of hepcidin positive rates in tissues and hepcidin levels in serum were related to clinical stages and distant metastasis, but not with sex, gender, tumor differentiation degree, pathological pattern and lymphatic metastasis. There is no relationship between the levels of hepcidin in tumor tissues and serum. Conclusion: Hepcidin positive rates in tissues and levels in serum were related to clinical stages and distant metastasis in NSCLC patients. Further study is needed to explore the mechanism.
Keywords: non-small cell lung cancer hepcidin immunohistochemistry metastasis