文章摘要

血管内NK/T细胞淋巴瘤的研究进展

作者: 1徐嘉雯, 2王宏量, 3赵文博, 1曹智新
1 山东大学附属省立医院病理科,济南 250021
2 山东省职业卫生与职业病防治研究院,山东省医学科学院,济南 250062
3 山东大学附属省立医院血液科,济南 250021
通讯: 曹智新 Email: caozhixin12@126.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.028
基金: 国家自然科学基金, 81202092 山东省重点研发计划项目 2015GSF118015,2016GSF201087

摘要

血管内NK/T细胞淋巴瘤(intravascular NK/T cell lymphoma,IVNKTL)罕见,其特征性表现为肿瘤性淋巴细胞选择性生长于血管腔内。不同地域患者临床表现多样且缺乏特异性,因此临床诊断困难。IVNKTL具有病程进展快、伴EBV感染、好发于亚洲,且以中国人多发等特点。在肿瘤未累及到多器官前进行早期诊治可有效改善IVNKTL患者的预后。
关键词: 血管内淋巴瘤 NK/T细胞淋巴瘤 临床病理学 鉴别诊断

Research progress in intravascular NK/T cell lymphoma

Authors: 1XU Jiawen, 2WANG Hongliang, 3ZHAO Wenbo, 1CAO Zhixin
1 Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021
2 Laboratory of Physical and Chemical Analysis, Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Jinan 250062
3 Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

CorrespondingAuthor: CAO Zhixin Email: caozhixin12@126.com

DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.028

Abstract

Intravascular NK/T cell lymphoma (IVNKTL) is a rare type of malignant lymphoma characterized by the selective growth of neoplastic lymphocytes within the lumina of blood vessels. The clinical manifestations are diverse and non-specific in different geographical areas, making diagnosis difficult. IVNKTL is a highly aggressive and EBV-associated lymphoma that is prone to develop in Asian patients, particularly in Chinese patients. Early diagnosis and treatment before multi-organ involvement could effectively improve the prognosis of IVNKTL patients.
Keywords: intravascular lymphoma natural killer/T cell lymphoma clinical pathology differential diagnosis