文章摘要

转录因子Nanog在恶性肿瘤发展中的作用

作者: 1解丽君, 2赵松
1 河北省疾病预防控制中心药物研究所,石家庄 050021
2 河北医科大学基础医学院病理教研室,石家庄 050017
通讯: 赵松 Email: 11217206@qq.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.030

摘要

Nanog是一个参与胚胎干细胞自我更新的转录因子,在多能细胞保持未分化状态的维持中起关键性作用。越来越多的资料表明Nanog基因在肿瘤细胞恶性表型的发展过程中异常高表达。Nanog特异性参与肿瘤的发生过程,是一种潜在的恶性肿瘤生物学和预后的标志物。
关键词: Nanog 肿瘤干细胞 肿瘤发生

Role of transcriptional factor Nanog in the development of malignant tumor

Authors: 1XIE Lijun, 2ZHAO Song
1 Institute of Materia Medical, Hebei Provincial Center for Disease Prevention and Control, Shijiazhuang 050021
2 Department of Pathology, Hebei Medical University, Shijiazhuang 050017, China

CorrespondingAuthor: ZHAO Song Email: 11217206@qq.com

DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.030

Abstract

Nanog is a transcription factor that is involved in the self-renewal of embryonic stem cells (ES) and is a critical factor for the maintenance of the undifferentiated state of pluripotent cells. Extensive data in the literature show that the Nanog gene is aberrantly expressed during the development of malignancy in cancer cells. Nanog is specifically involved in the process of carcinogenesis and can be a potential biological and prognostic marker for malignant tumors.
Keywords: Nanog cancer stem cell carcinogenesis