文章摘要

脑死亡动物模型的研究进展

作者: 1王建桥, 2吕浩同, 3李战永
1 河北省廊坊市人民医院神经内科,河北 廊坊 065000
2 华北理工大学临床医学院2013级,河北 唐山 063000
3 廊坊师范学院生命科学学院,河北 廊坊 065000
通讯: 李战永 Email: lee1537@126.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.033

摘要

脑死亡动物模型可用于研究器官移植供体的功能,大鼠、猪、狗、家兔、小鼠等是脑死亡动物模型常选用的模式动物。当前具有代表性的脑死亡建模方法,是通过急剧或缓慢颅内加压法建模,制备突发性脑死亡模型和渐进性脑死亡模型。模式动物脑死亡的判定目前尚无统一标准,现有脑死亡动物模型仍存在不足,不能全面模拟临床脑死亡,建模成功的判断与临床上脑死亡的诊断仍有差别。
关键词: 脑死亡 模式动物 突发性脑死亡模型 渐进性脑死亡模型

Research progress of animal model of brain death

Authors: 1WANG Jianqiao, 2LÜ Haotong, 3LI Zhanyong
1 Department of Neurology, People’s Hospital of Langfang City, Langfang Hebei 065000
2 College of Clinical Medicine, North China University of Science and Technology, Tangshan Hebei 063000
3 College of Life Science, Langfang Teachers University, Langfang Hebei 065000, China

CorrespondingAuthor: LI Zhanyong Email: lee1537@126.com

DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.033

Abstract

Brain death models can be used to study the function of transplant donor. Rats, pigs, dogs, rabbits, mice, etc. are often selected for model animals used in brain death studies. Currently, the typical method to establish a brain death model is to increase intracranial pressure suddenly or gradually by inflation of an epidural balloon catheter. The commonly applied models are sudden onset brain death model and gradual onset brain death model. There are still no uniform criteria for the determination of brain death in the model animal. Additionally, some deficiencies of brain death animal models at present are existed yet, and it cannot fully simulate the clinical brain death. The judgment of a successful brain death model is still different from the diagnosis of clinical brain death.
Keywords: brain death model animal the sudden onset brain death model the gradual onset brain death model