文章摘要

十二指肠神经节细胞副神经节瘤临床病理观察

作者: 1奚丽娜, 1赵卫星
1 新乡医学院第一附属医院病理科,河南 新乡 453100
通讯: 赵卫星 Email: zwx9@xxmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.039

摘要

收集1例42岁十二指肠神经节细胞副神经节瘤(ganglioeytic paraganglioma,GP)男性患者的临床资料,对手术标本采用HE染色及免疫组织化学染色进行病理学观察,并复习国内外文献报道的相关病例进行临床及病理学特征分析。光镜下可见3种细胞成分:神经内分泌细胞、伴神经鞘细胞分化的梭形细胞(梭形细胞)和神经节细胞。神经内分泌细胞呈假腺管样结构排列,细胞胞质嗜酸性,核卵圆形,大小一致,无核分裂象;梭形细胞形成小的束状结构,包绕神经内分泌细胞;节细胞散在分布。3种细胞均无明显的细胞异型性。在该病例中还可见到小束状的平滑肌成分。免疫组织化学:神经内分泌细胞CgA,Syn,CD56和CK阳性,梭形细胞S-100和vimentin阳性,节细胞S-100和NF阳性。十二指肠GP是一种罕见的肿瘤,十二指肠各个部位均可发生,依据其特征性的镜下表现并结合免疫组织化学可做出正确诊断。
关键词: 神经节细胞副神经节瘤 十二指肠肿瘤 免疫组化

Clinicopathological observation of duodenal Ganglion paraganglioma

Authors: 1XI Lina, 1ZHAO Weixing
1 Department of Pathology, First Affiliated Hospital of Xinxiang Medical University, Xinxiang Henan 453100, China

CorrespondingAuthor: ZHAO Weixing Email: zwx9@xxmu.edu.cn

DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2017.09.039

Abstract

The clinical data of a 42-year-old male patient with duodenal ganglion paraganglioma were collected. HE staining and immunohistochemical staining were used to observe the pathological changes of the surgical specimens. The clinical and pathological features were analyzed by review the relevant cases reported in the literature at home and abroad. There are 3 cell components seen under the microscope: neuroendocrine cells, spindle cells with Schwann cell-like differentiation (spindle cells) and ganglion cells. The neuroendocrine cells were arranged in pseudo glandular tubular structure, eosinophilic cytoplasm, with the same size of the oval nucleus and without nuclear fission. The spindle cells formed small bundles, wrapped in neuroendocrine cells; the ganglion cells are scattered distribution; there was no obvious cell atypia in the 3 kinds of cells. Wispy smooth muscle component was seen in this case, too. Immunohistochemistry showed neuroendocrine cells were positive for CgA, Syn,CD56 and CK, spindle cells were positive for S-100 and vimentin, Ganglion cells were positive for S-100 and NF. Duodenal ganglion paraganglioma is a rare tumor and each part of duodenal may occur. The correct diagnosis can be made according to the characteristics of the microscopic performance and immunohistochemistry.
Keywords: ganglion paraganglioma tumor of duodenum immunohistochemistry