文章摘要

MTH1 在非小细胞肺癌中的表达及其与预后的关系

作者: 1宋玉, 1胡轶
1 华中科技大学同济医学院附属武汉中心医院呼吸科,武汉 430000
通讯: 胡轶 Email: huyin834@126.com
DOI: 10.3978/j.issn.2095-6959.2019.03.010

摘要

目的:评估mutT同系物1(mutT homolog 1,MTH1)在非小细胞肺癌(non-small lung cance cell , NSCLC)中的表达及与预后的关系。方法:收集2011年3月至2013年3月于华中科技大学同济医学院附属武汉中心医院行肺癌切除术的100例患者的肺癌组织,分成MTH1高表达组和低表达组。免疫组织化学评估MTH1蛋白的表达并分析其与患者临床病理因素的关系。Kaplan-Meier生存曲线分析MTH1的表达与预后间的关系,Cox比例风险模型分析影响总生存率和无瘤生存率的危险因素。结果:MTH1在57%的NSCLC组织中高表达,在43%的NSCLC组织中低表达。MTH1 高表达与吸烟(P=0.031)、病理类型(P=0.001)、TNM分期(P<0.001)、淋巴结转移(P<0.001)、血管侵犯(P<0.001)和胸膜侵犯( P<0.001)相关,MTH1高表达组1、5年总生存率低于MTH1低表达组(P<0.05);MTH1高表达组1、5年无瘤生存率低于MTH1低表达组(P<0.05)。TNM分期(P=0.008)、淋巴结转移(P<0.001)及MTH1表达(P=0.047)为影响总生存率的独立危险因素,多因素分析示淋巴结转移(P<0.001)及MTH1表达(P=0.039)为影响无瘤生存率的独立危险因素。结论:MTH1在非小细胞肺癌中高表达,且与恶性临床病理特征相关,MTH1高表达的患者无瘤生存率和总生存率低于MTH1低表达的患者,MTH1高表达是影响非小细胞肺癌预后的独立危险因子。
关键词: mutT同系物1;非小细胞肺癌;预后

Expression of MTH1 in patients with non-small lung cancer cell and its association with prognosis

Authors: 1SONG Yu, 1HU Yi
1 Department of Respiration, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China

CorrespondingAuthor: HU Yi Email: huyin834@126.com

DOI: 10.3978/j.issn.2095-6959.2019.03.010

Abstract

Objective: To investigate the expression of mutT homolog 1 (MTH1) in non-small lung cance cell (NSCLC) patients and its association with prognosis. Methods: One hundred of NSCLC patients tissues diagnosed in The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology from March 2011 to March 2013 were collected and divided into a MTH1 over-expressed group and a MTH1 low-expressed group. Immunohistochemistry was used to evaluate the expression of MTH1 protein. The relationship between MTH1 expression and clinical characteristics of patients was analyzed. Kaplan-Meier survival curve was used to analyze the relationship between expression of MTH1 and prognosis of patients. The Cox proportional hazards model was used to analyze the independent risk factors of overall survival and disease-free survival. Results: MTH1 was highly expressed in 57 cases (57%) and low expression in 43 cases (43%). High expression of MTH1 was significantly associated with smoking state (P=0.031), pathology types (P=0.001), TNM stage (P<0.001), lymph node metastasis (P<0.001), vascular infiltration (P<0.001) and pleural invasion (P<0.001). The 1-, 5-year overall survival rates of MTH1 over-expressed group was significantly lower than that in MTH1 low-expressed group (P<0.05). The 1-, 5-year disease-free survival rates of MTH1 over-expressed group was significantly lower than that in MTH1 low-expressed group (P<0.05). TNM stage (P=0.008), lymph node metastasis (P<0.001) and MTH1 expression (P=0.047) were independent risk factors of overall survival. While lymph node metastasis (P<0.001) and MTH1 expression (P=0.039) were independent risk factors of disease-free survival. Conclusion: MTH1 protein is over-expressed in NSCLC tissues, which is significantly associated with malignant characteristics. Patients with high MTH1 expression have lower disease-free and overall survival rates than those with low expression of MTH1. MTH1 over-expression is an independent risk factor for the prognosis of non-small cell lung cancer.
Keywords: mutT homolog 1; non-small cell lung cancer; prognosis