文章摘要

术前血液学相关指标与喉癌患者的预后

作者: 1石峰, 1赵国锋, 1胡艳红, 1姜永刚, 1张刚, 2李冬梅
1 唐山市协和医院耳鼻喉科,河北 唐山 063100
2 开滦职业病防治院耳鼻喉科,河北 唐山 063301
通讯: 石峰 Email: 3479435495@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.03.013

摘要

目的:探究术前血液学相关指标与喉癌患者预后的关系。方法:回顾性分析2011年3月至2012年 5月在唐山市协和医院进行手术治疗的102例喉癌患者的临床资料。根据术前静脉血中性粒细 胞/淋巴细胞的比值(neutrophi l/ly mphoc y te rat io ,NLR)分为高NLR组( n= 37)与低NLR组(n=65)。比较两组患者临床病理学特征、凝血指标、5年总体生存率及影响患者生存率、预后的因素。结果:两组患者在年龄、性别方面差异无统计学意义(P>0.05);但低NLR组在肿瘤分型、分化程度、T分级、N分级及临床分期等方面,与高NLR组的差异有统计学意义(P<0.05)。高NLR组凝血酶原时间(prothrombin time,PT)、激活部分凝血酶原时间(activated partial thromboplastin time,APTT)水平显著高于低NLR组(P<0.05);高NLR组纤维蛋白原(f ibrinogen,FIB)、血小板( platelet,PLT)水平显著低于低NLR组(P<0.05)。低NLR组的5年生存率为86.15%,高NLR组的 5年生存率为54.05%,二者比较,差异有统计学意义(P<0.05)。喉癌患者5年生存率与肿瘤分型、肿瘤组织的分化程度、T分级、N分级及临床分期呈正相关(P<0.05)。肿瘤分型、组织分化程度、淋巴结转移、T分级、N分级、临床分期、NLR是影响患者预后的独立因素。结论:术前血液中NLR>3.2是影响喉癌患者预后的独立危险因素。
关键词: 喉癌;中性粒细胞/淋巴细胞的比值;生存率;预后

Preoperative hematological parameters and prognosis of patients with laryngeal carcinoma

Authors: 1SHI Feng, 1ZHAO Guofeng, 1HU Yanhong, 1JIANG Yonggang, 1ZHANG Gang, 2LI Dongmei
1 Department of Otolaryngology, Tangshan Union Hospital, Tangshan Hebei 063100, China
2 Department of Otolaryngology, Kailuan Occupational Disease Prevention and Treatment Hospital, Tangshan Hebei 063301, China

CorrespondingAuthor: SHI Feng Email: 3479435495@qq.com

DOI: 10.3978/j.issn.2095-6959.2019.03.013

Abstract

Objective: To explore the relationship between preoperative blood-related parameters and prognosis of laryngeal cancer patients. Methods: The clinical data of 102 patients with laryngeal cancer who underwent surgery in our hospital from May 2011 to May 2012 were retrospectively analyzed. According to the preoperative venous blood neutrophil/lymphocyte ratio (NLR), the patients were divided into a high NLR group (n=37) and a low NLR group (n=65). The clinical pathological features, coagulation parameters, 5-year overall survival, and factors influencing patient survival and prognosis were compared between the two groups. Results: There was no significant difference in age and gender between the two groups (P>0.05). However, there was a significant difference between the low NLR group in tumor classification, differentiation, T-grade, N-grade, and clinical stage in the high NLR group (P<0.05). The prothrombin time (PT) and activated partial prothrombin time (APTT) levels in the high NLR group were significantly higher than those in the low NLR group (P<0.05); the fibrinogen (FIB) and platelet (PLT) levels were significantly lower in the high NLR group. In the low NLR group (P<0.05). The survival rate in the low NLR group was 86.15%; the 5-year survival rate in the high NLR group was 54.05%; the 5-year survival rate in the low NLR group was significantly higher than that in the high NLR group (P<0.05). The 5-year survival rate of patients with laryngeal cancer was positively correlated with tumor type, tumor tissue differentiation, T-grade, N-grade and clinical stages (P<0.05). Tumor typing, degree of tissue differentiation, lymph node metastasis, T-grade, N-grade, clinical stage, and NLR were independent factors for the prognosis of patients. Conclusion: The preoperative blood NLR >3.2 is an independent risk factor for the prognosis of laryngeal cancer patients.
Keywords: laryngeal cancer; neutrophil/lymphocyte ratio; survival rate; prognosis