文章摘要

外用10%和15%氢氧化钾治疗传染性软疣的有效性和安全性

作者: 1周发琼, 1雷淑英
1 恩施土家族苗族自治州中心医院皮肤科,湖北 恩施 445000
通讯: 雷淑英 Email: leishuyingpifu@163.com
DOI: 10.3978/j.issn.2095-6959.2019.03.022

摘要

目的:比较不同浓度氢氧化钾水溶液对儿童传染性软疣(molluscum contagiosum,MC)皮损的治疗效果,同时评估其安全性、耐受性以及不良反应。方法:随机选取恩施州中心医院53例患儿,年龄2~6岁,使用双盲随机临床对照试验原则将受试人群分为3组(10%氢氧化钾治疗组,15%氢氧化钾治疗组,对照组),患儿每天接受1次治疗,直到皮损消失,治疗时间不超过60 d。结果:10%氢氧化钾治疗组治疗有效率为58.8%,15%氢氧化钾治疗组治疗有效率为64.3%,均高于对照组(18.8%),差异有统计学意义(P<0.05)。10%氢氧化钾治疗组与15%氢氧化钾治疗组的治疗有效率差异并无统计学意义(P>0.05)。相对于15%氢氧化钾组,10%氢氧化钾组和对照组耐受性更好,且发生不良反应比例更低。结论:10%和15%氢氧化钾治疗MC均能获得良好的治疗效果,10%氢氧化钾具有更好的治疗耐受性。
关键词: 有效性;传染性软疣;儿童;氢氧化钾;随机对照临床试验;安全性

Efficacy and safety of topical application of 10% and 15% potassium hydroxide for the treatment of molluscum contagiosum

Authors: 1ZHOU Faqiong, 1LEI Shuying
1 Department of Dermatology, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Hubei 445000, China

CorrespondingAuthor: LEI Shuying Email: leishuyingpifu@163.com

DOI: 10.3978/j.issn.2095-6959.2019.03.022

Abstract

Objective: To compare the efficacy of topical treatment with potassium hydroxide at different concentrations with that of placebo in terms of complete clearing of molluscum contagiosum lesions and to assess the safety and tolerance of topical treatment with potassium hydroxide. Methods: A double-blind randomized clinical trial was conducted. A total of 53 children, aged 2–6 years, were assigned into 3 groups. Ten percent of potassium hydroxide 10%, 15% of potassium hydroxide, and placebo were applied once daily up to complete clearing of lesions (maximum duration 60 days). Results: The main efficacy outcome was 58.8% in the 10% potassium hydroxide group (P=0.03 vs placebo) and 64.3% in the 15% potassium hydroxide group (P=0.02 vs placebo). Two potassium hydroxide groups were not significantly different in efficacy from each other. The 10% potassium hydroxide group and the placebo group were better tolerated than the 15% potassium hydroxide group. Subjects receiving 10% potassium hydroxide and placebo had higher proportions of adverse events than those receiving 15% potassium hydroxide. Conclusion: Potassium hydroxide (10% and 15%) demonstrated high rates of efficacy in clearing molluscum contagiosum lesions, and 10% potassium hydroxide is better tolerated.
Keywords: efficacy; molluscum contagiosum; paediatrics; potassium hydroxide; randomized clinical trial; safety