文章摘要

25-羟维生素D与糖尿病肾病的相关性研究进展

作者: 1杨红丽, 1李素梅
1 安徽医科大学附属省立医院内分泌与代谢病科,合肥 230001
通讯: 李素梅 Email: lisumei0808@126.com
DOI: 10.3978/j.issn.2095-6959.2019.03.031

摘要

糖尿病肾病是2型糖尿病(type 2 diabetes mellitus,T2DM)最常见并发症之一,为微血管损伤引起的肾功能损伤,其发生发展机制复杂,维生素D的缺乏与不足可能与糖尿病肾病的发生具有一定的相关性。维生素D作为钙磷调节药在临床上广泛应用,近年研究表明T2DM合并肾病患者存在严重的维生素D缺乏,具有活性的维生素D在T2DM发展、糖尿病肾病进展中发挥着保护作用,这种作用与经典钙磷调节模式不尽相同。
关键词: 25-羟维生素D;糖尿病肾病;2型糖尿病

Advances in research on the relationship between 25-hydroxyvitamin D and diabetic nephropathy

Authors: 1YANG Hongli, 1LI Sumei
1 Department of Endocrinology and Metabolism, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China

CorrespondingAuthor: LI Sumei Email: lisumei0808@126.com

DOI: 10.3978/j.issn.2095-6959.2019.03.031

Abstract

Diabetic nephropathy is one of the most common complications of type 2 diabetes mellitus (T2DM), which is one kind of the damage of renal function caused by microvascular damage, whose occurrence and development mechanism are complex. The deficiency and deficiency of vitamin D may be correlated with the occurrence of diabetic nephropathy. Vitamin D is widely used as calcium phosphate regulator in clinic. In recent years, studies have shown that patients with T2DM with nephropathy exist severe vitamin D deficiency. Having the activity of vitamin D plays a protective role in the development of T2DM and diabetic nephropathy progress. This effect is not the same as the classical calcium phosphate adjustment mode. This paper will make a brief discussion about the study correlation between the 25-hydroxy vitamin D levels and diabetic nephropathy.
Keywords: 25-hydroxyvitamin D; diabetic nephropathy; type 2 diabetes mellitus