文章摘要

二甲双胍治疗原发性肝癌的研究进展

作者: 1孔顺, 1杨志叶, 1强云沐, 1刘彪, 1孙娟君
1 芜湖市第二人民医院药剂科,安徽 芜湖 241000
通讯: 孔顺 Email: cqxiong8@163.com
DOI: 10.3978/j.issn.2095-6959.2019.03.032

摘要

原发性肝癌(primar y hepatocellular carcinoma,PHC)是一种常见的恶性肿瘤,其危害性较大。针对PHC的药物研发,对于肝癌的防治具有重要意义。近年来研究发现,糖尿病患者使用二甲双胍后,其PHC发病率下降。因此,二甲双胍对于PHC具有一定的治疗作用。
关键词: 原发性肝癌;二甲双胍;治疗;分子机制

Advances in the treatment of primary hepatocellular carcinoma treatment with metformin

Authors: 1KONG Shun, 1YANG Zhiye, 1QIANG Yunmu, 1LIU Biao, 1SUN Juanjun
1 Department of Pharmacy, Second People’s Hospital of Wuhu, Wuhu Anhui 241000, China

CorrespondingAuthor: KONG Shun Email: cqxiong8@163.com

DOI: 10.3978/j.issn.2095-6959.2019.03.032

Abstract

Primary hepatocellular carcinoma (PHC) is a common malignant tumor with greater harmfulness. The research and development of drugs against PHC is of great significance for the prevention and treatment of PHC. Studies in recent years have found that the incidence of PHC in diabetic patients treated with metformin was decreased. Therefore, metformin has certain therapeutic and preventive effects on PHC.
Keywords: primary hepatocellular carcinoma; metformin; treatment; molecular mechanism