文章摘要

血小板聚集率和凝血试验相关参数在危重烧伤患者中的变化及临床意义

作者: 1卢蕾, 1王亚萍, 1黄璇, 1卢志贤
1 无锡市第三人民医院检验科,江苏 无锡 214041
通讯: 卢志贤 Email: seed001lzx@163.com
DOI: 10.3978/j.issn.2095-6959.2019.12.011

摘要

目的:探讨血小板聚集率(PAGT:MAR)和凝血试验相关参数在危重烧伤患者中的变化及临床意义。方法:根据烧伤危重程度惯用分类标准将来自无锡市第三人民医院的87例危重烧伤患者分为2组:重度组52例和特重度组35例,检测两组危重烧伤患者入院当天(0 d),1 d,2 d,3 d,4 d,5 d,6 d的PAGT:MAR、D-二聚体(D-D)、纤维蛋白原(Fbg)水平、抗凝血酶III(AT-III)活性、血小板(PLT)并进行动态观察,同时选择100例健康体检者作为正常对照组。结果:2组危重烧伤患者入院0 d,1 d PAGT:MAR,PLT均明显高于对照组(P<0.01),入院2~6 d PAGT:MAR,PLT均明显低于对照组(P<0.01);2组危重烧伤患者入院0 d,1 d Fbg,AT-III活性均明显低于对照组(P<0.01),入院2~6 d Fbg,AT-III活性均明显高于对照组(P<0.01);2组危重烧伤患者D-D入院0~6 d均明显高于对照组(P<0.01)。2组中轻度烧伤患者入院0~6 d内 PAGT:MAR,D-D,Fbg,PLT,AT-III湖对照组差异无统计学意义(P>0.05)。结论:PAGT:MAR和凝血试验相关参数在危重烧伤患者中的变化能够全面准确地反映患者存在的凝血系统障碍、纤溶系统功能异常,应引起临床医生的高度重视,可为治疗及预后判断提供依据。
关键词: 血小板聚集率;凝血试验相关参数;危重烧伤

Changes in platelet aggregation rate and thrombotest parameters in severe burned patients and their clinical significance

Authors: 1LU Lei, 1WANG Yaping, 1HUANG Xuan, 1LU Zhixian
1 Department of Clinical Laboratory, Third People’s Hospital of Wuxi, Jiangsu Wuxi 214041, China

CorrespondingAuthor: LU Zhixian Email: seed001lzx@163.com

DOI: 10.3978/j.issn.2095-6959.2019.12.011

Abstract

Objective: To evaluate the clinical significance of platelet aggregation rate and thrombotest parameters in severe burned patients. Methods: According to the severity of the usual burn classification standard, 87 cases of severe burn patients were divided into the 2 groups: the severe group (52 cases) and the special severe group (35 cases). The levers of 0 day, 1 day, 2 days, 3 days, 4 days, 5 days, 6 days of platelet aggregation rate (PAGT:MAR), D-dimer (D-D), fibrinogen (Fbg), antithrombin III (AT-III) activity, platelet (PLT) were observed. At the same time, 100 healthy subjects served as normal control group. Results: The levers of PAGT:MAR, PLT 0, 1 day in the two severe burn groups were significance higher than control group (all P<0.01), and these 2–6 days were significance lower than control group (all P<0.01). The levers of Fbg, AT-III activity 0, 1 day in the two severe burn groups were significance lower than control group (all P<0.01), and these 2–6 days were significance higher than control group (all P<0.01). But the levers of D-D in the two severe burn groups were always significance higher than control group (all P<0.01). There were no significant differences about PAGT:MAR, D-D, Fbg, PLT and AT-III between moderate and mild burn patients and controls between 0 and 6 days after admission (P>0.05). Conclusion: The changes of platelet aggregation and thrombotest parameters in patients with severe burn injuries may reflect the dysfunction of coagulation system and fibrinolytic system. They may provide the basis for treatment and prognosis.
Keywords: platelet aggregation rate; thrombotest parameters; severe burn injury