文章摘要

儿童外周神经母细胞性肿瘤临床病理因素与预后的相关性

作者: 1方园, 1王一真, 1黎绍梅
1 安徽省儿童医院病理科,合肥 230051
通讯: 方园 Email: 522656049@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.12.015

摘要

目的:探讨儿童外周神经母细胞性肿瘤临床病理因素与预后的相关性。方法:收集119例外周神经母细胞性肿瘤患儿的年龄、性别、发病部位、临床分期、病理类型、核碎裂指数(mitosis karyorrhexis index,MKI)、Ki-67指数、治疗方式以及预后情况,通过绘制Kaplan-Meier生存曲线、进行Log-rank χ2检验以及Cox回归模型分析,探讨影响患儿预后的相关因素。结果:119例患儿中男72例、女47例,年龄平均28.07个月,生存时间平均48.74个月。单因素分析显示年龄、部位、临床分期、Ki-67指数及治疗方式与预后有一定相关性,多因素分析显示临床分期与治疗方式是预后的独立影响因素(P<0.05)。结论:外周神经母细胞性肿瘤儿童常见且病死率高,尽早诊断、明确分期,并综合检查结果制订合适的治疗方式,对于改善患儿预后具有一定的临床意义。
关键词: 儿童;外周神经母细胞性肿瘤;临床病理因素;预后

Correlation between clinicopathological factors and prognosis in children’s peripheral neuroblastic tumors

Authors: 1FANG Yuan, 1WANG Yizhen, 1LI Shaomei
1 Department of Pathology, Anhui Provincial Children’s Hospital, Hefei 230051, China

CorrespondingAuthor: FANG Yuan Email: 522656049@qq.com

DOI: 10.3978/j.issn.2095-6959.2019.12.015

Abstract

Objective: To investigate the correlation between clinicopathological factors and prognosis in children’s peripheral neuroblastic tumors. Methods: The age, sex, location, clinical stage, pathological type, mitosis karyorrhexis index (MKI), Ki-67 index, treatment and prognosis of peripheral neuroblastic tumors in 119 cases were collected. Then Kaplan-Meier survival curves were drawn, with the Log-rank χ2 test and Cox regression model were used to explore the factors that may influence the prognosis of patients. Results: There were 72 boys and 47 girls with an average age of 28.07 months and an average survival time of 48.74 months. Univariate analysis showed that age, location, clinical stage, Ki-67 index and treatment were associated with prognosis. While multivariate analysis showed that clinical stage and treatment were independent prognostic factors (P<0.05). Conclusion: Peripheral neuroblastic tumors, which are common in pediatric patients, usually have a high mortality rate. Early diagnosis and clear staging, combining with appropriate treatments result from comprehensive examinations, may have a certain clinical significance for improving the prognosis of pediatric patients.
Keywords: children; peripheral neuroblastic tumor; clinicopathological factor; prognosis