文章摘要

红细胞分布宽度与老年反杓型高血压患者早期肾功能损伤的关系

作者: 1姜惠敏, 2黄立纲, 1牛芊, 1张振民, 1洪艳英
1 首都医科大学附属北京中医医院检验科,北京 100010
2 清华大学附属第一医院检验科,北京 100084
通讯: 洪艳英 Email: fengboxie@163.com
DOI: 10.3978/j.issn.2095-6959.2019.12.022

摘要

目的:探讨红细胞分布宽度(red cell distribution width,RDW)与老年反杓型高血压患者早期肾功能损伤的关系。方法:选取2015年9月至2018年8月首都医科大学附属北京中医医院收治的老年反杓型高血压患者256例作为观察组,年龄匹配的老年非杓型高血压患者89例作为对照组。比较两组患者基线资料及其RDW、肌酐(Cr)、尿素氮、β2微球蛋白(β2-MG)、胱抑素C(CysC)、尿微量白蛋白(microalbuminuria,MAU)及肾小球滤过率(estimated glomerular filtration rate,eGFR),并进一步分析RDW与老年反杓型高血压患者β2-MG,MAU,CysC的关系。结果:观察组RDW,MAU,Cr,尿素氮,β2-MG,CysC高于对照组(P<0.05),而eGFR低于对照组(P<0.05);Pearson相关分析示对照组RDW值与β2-MG(r=0.212,P<0.05),MAU(r=0.357,P<0.05),CysC呈显著正相关(r=0.236,P<0.05);多元线性Logistic回归分析示RDW(OR=1.91,95%CI 1.06~3.19,P=0.03),β2-MG(OR=4.12,95%CI 2.05~8.31,P<0.001),MAU(OR=0.42,95%CI 0.20~0.79,P=0.01)是老年反杓型高血压患者肾损伤的危险因素。结论:RDW是老年反杓型高血压患者早期肾损伤的影响因素,提示其可作为此类患者早期肾功能损伤的独立预测指标。
关键词: 红细胞分布宽度;反杓型高血压;肾功能损伤;老年;早期

Relationship between red cell distribution width and early renal damage in elderly patients with anti-dipper hypertension

Authors: 1JIANG Huimin, 2HUANG Ligang, 1NIU Qian, 1ZHANG Zhenmin, 1HONG Yanying
1 Department of Clinical Laboratory, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing 100010, China
2 Department of Clinical Laboratory, First Affiliated Hospital of Tsinghua University, Beijing 100084, China

CorrespondingAuthor: HONG Yanying Email: fengboxie@163.com

DOI: 10.3978/j.issn.2095-6959.2019.12.022

Abstract

Objective: To analyze the relationship between red cell distribution width and early renal damage in elderly patients with anti-dipper hypertension. Methods: From September 2015 to August 2018 in Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, a total of 256 elderly patients with anti-dipper hypertension were selected as an observation group, meanwhile 89 old people with non-dipper hypertension were selected as a control group. Baseline of two group and the following index: red cell distribution width, Microalbuminuria (MAU), blood urea nitrogen, creatinine, β2 microglobulin (β2-MG), cystatin C (CysC), glomerular filtration rate were compared between the two groups, and then analyzed the relationship between red cell distribution width and MAU, β2-MG, CysC in elderly patients with anti-dipper hypertension. Results: Red cell distribution width, MAU, blood urea nitrogen, creatinine, β2-MG and CysC of observation group were statistically significantly higher than those of control group (P<0.05), while glomerular filtration rate of observation group was statistically significantly lower than that of control group (P<0.05). Pearson correlation analysis results showed that red cell distribution width was correlated with β2-MG (r=0.212, P<0.05), MAU (r=0.357, P<0.05), CysC (r=0.236, P<0.05). Multivariate linear regression analysis results showed that red cell distribution width (OR=1.91, 95%CI 1.06–3.19, P=0.03), β2-MG (OR=4.12, 95%CI 2.05–8.31, P<0.001), MAU (OR=0.42, 95%CI 0.20–0.79, P=0.01) were the influencing factors of renal impairment in elderly patients with anti-dipper hypertension. Conclusion: Red cell distribution width is the influencing factor of early renal impairment in elderly patients with anti-dipper hypertension, suggesting that red cell distribution can be used as an indicator for early renal impairment in these patients with anti-dipper hypertension.
Keywords: red cell distribution width; anti-dipper hypertension; renal impairment; aged; early