文章摘要

影响前颅底脑膜瘤患者术后疗效的多因素分析

作者: 1刘朋, 1华磊, 1吕岳, 1丁飞, 1刘宇昊, 1戴如飞, 1冯力
1 徐州医科大学附属医院神经外科,江苏 徐州 221000
通讯: 冯力 Email: david1371@163.com
DOI: 10.3978/j.issn.2095-6959.2019.12.027
基金: 江苏省自然科学基金(BK20181152)。

摘要

目的:探讨影响前颅底脑膜瘤患者术后疗效的临床因素。方法:回顾性分析2015年1月至2019年1月就诊于徐州医科大学附属医院的61例前颅底脑膜瘤患者的临床资料,采用随访时卡氏功能状态评分(Karnofsky Performance Status,KPS)量表评估患者术后疗效,行单因素分析,多因素logistic回归分析明确各因素(患者性别、年龄、有无局灶性神经功能障碍,肿瘤的病理分级、大小、部位、质地、有无钙化或水肿、切除程度、与脑组织分界及是否包绕血管神经)与术后疗效的关系。结果:单因素分析结果显示患者有无局灶性神经功能障碍、肿瘤与脑组织分界及是否包绕血管神经与术后疗效显著相关(P<0.05),而患者的性别、年龄,肿瘤的病理分级、大小、部位、质地、切除程度及有无钙化或水肿与术后疗效无关(P>0.05)。Logistic回归分析显示患者有无局灶性神经功能障碍及肿瘤是否包绕血管神经为影响患者术后疗效的因素(P=0.004,P=0.023)。结论:无局灶性神经功能障碍及肿瘤未包绕血管神经的前颅底脑膜瘤患者的预后较好。
关键词: 前颅底;脑膜瘤;疗效;影响因素

Multivariate analysis of factors affecting the postoperative efficacy of patients with anterior skull base meningioma

Authors: 1LIU Peng, 1HUA Lei, 1LÜ Yue, 1DING Fei, 1LIU Yuhao, 1DAI Rufei, 1FENG Li
1 Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221000, China

CorrespondingAuthor: FENG Li Email: david1371@163.com

DOI: 10.3978/j.issn.2095-6959.2019.12.027

Foundation: This work was supported by the National Natural Science Foundation of Jiangsu Province, China (BK20181152).

Abstract

Objective: To investigate the relevant clinical factors affecting the postoperative efficacy of patients with anterior skull base meningioma. Methods: A retrospective analysis of clinical data of 61 patients with anterior skull base meningioma was conducted between January 2015 and January 2019 in the Affiliated Hospital of Xuzhou Medical University. The postoperative efficacy was comprehensively evaluated according to the preoperative and postoperative follow-up Karnofsky Performance Scale (KPS) of the patients. Statistical analysis of single factor and logistic regression model of multivariate factors were conducted to determine the relationship between each factor (gender, age, presence or absence of focal neurological dysfunction, pathologic grade, tumor size, tumor location, tumor texture, presence or absence of calcification or edema, extent of tumor resection, boundary of tumor and cerebral tissue, and inclusion of vascular nerves or not) and postoperative efficacy. Results: Single factor analysis results show the postoperative efficacy was significantly correlated with the presence or absence of focal neural dysfunction in patients, boundary between tumor and cerebral tissue as well as inclusion of vascular nerves or not (P<0.05), gender, age, pathologic grade, tumor texture, presence or absence of calcification or edema, tumor size, tumor location and extent of resection, however, were not correlated with the efficacy (P>0.05). Further dichotomy Logistic regression analysis demonstrated that presence or absence of focal neurological dysfunction and the inclusion of vascular nerves or not in the tumor were factors affecting the postoperative efficacy of the patients (P=0.004, P=0.023, respectively). Conclusion: The prognosis of patients with meningioma of the anterior cranial base without focal neurological dysfunction and tumor that does not surround vascular nerves is better.
Keywords: anterior skull base; meningioma; efficacy; factor