文章摘要

长期随访雷珠单抗联合康柏西普治疗年龄相关性黄斑变性1例

作者: 1,2彭立, 1陈敏华, 1谢青
1 海口市人民医院,中南大学湘雅医学院附属海口医院眼科,海口 570000
2 中南大学湘雅二医院眼科,长沙 410011
通讯: 谢青 Email: doc_xq@163.com
DOI: 10.3978/j.issn.2095-6959.2019.12.036

摘要

报告雷珠单抗联合康柏西普玻璃体腔注射治疗难治性年龄相关性黄斑变性(age-related macular degeneration,AMD)1例,患者经15次抗血管内皮生长因子(vascular endothelial growth factor,VEGF)治疗55个月后,视力从0.25提高维持至1.0,黄斑光学相干断层扫描成像(optical coherence tomography,OCT)提示病灶逐渐缩小并趋于稳定。抗VEGF是治疗AMD的首选有效方法,其个性化治疗非常重要,在治疗过程中还需考虑药物的延迟应答,且OCT在观察AMD的病情变化中具有良好的应用价值。
关键词: 雷珠单抗;康柏西普;年龄相关性黄斑变性;延迟应答

Long-term outcome with intravitreal injections of lucentis and conbercept in age-related macular degeneration: A case report

Authors: 1,2PENG Li, 1CHEN Minhua, 1XIE Qing
1 Department of Ophthalmology, Haikou People’s Hospital, Haikou Hospital Affiliated to Xiangya Medical College, Central South University, Haikou 570000, China
2 Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, China

CorrespondingAuthor: XIE Qing Email: doc_xq@163.com

DOI: 10.3978/j.issn.2095-6959.2019.12.036

Abstract

This paper reports 1 case of refractory age-related macular degeneration (AMD) treated with combined intravitreal injections of lucentis and conbercept 15 times. After 15 combined injections of lucentis and conbercept, the patient got a gradually increased best corrected visual acuity (BCVA) and a diminishing maculopathy on optical coherence tomography (OCT), both keeping stable at the end of visit. It reveals that intravitreal lucentis combined with conbercept appeared to be an effective treatment for refractory AMD. The management of AMD should be individualized or personalized according diagnosis time and delayed response of drugs. OCT has a good application value in observing the changes of macular anatomical changes in AMD.
Keywords: lucentis; conbercept; age-related macular degeneration; delayed response