文章摘要

血清CEA,CA125及CA199在肺结核诊断中的价值

作者: 1张婷, 1王亚楠, 1苗琪, 1田娟
1 中国人民解放军总医院第八医学中心核医学科,北京 100191
通讯: 张婷 Email: zhangting618@126.com
DOI: 10.3978/j.issn.2095-6959.2020.08.017

摘要

目的:探讨肺结核患者血清肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原199(carbohydrate antigen 199,CA199)水平变化及其临床价值。方法:选取111例肺结核患者(肺结核组)、60例肺癌患者(肺癌组)以及60例健康体检者(对照组),检测并比较各组血清肿瘤标志物CEA,CA125,CA199水平,评估各肿瘤标志物在肺结核中的诊断价值。结果:各组血清CEA,CA125,CA199水平比较,差异有统计学意义(均P<0.05)。肺癌组血清CEA,CA199水平明显高于肺结核组和对照组(P<0.05);肺结核组血清CA125明显高于肺癌组和对照组(均P<0.01);肺癌组CA199水平明显高于对照组(P<0.05)。血清CA125的受试者工作特征曲线下面积(AUC)值为0.745(95%CI:0.711~0.861,P<0.001),其灵敏度为81.8%,特异度为62.3%。各肿瘤标志物联合检测的AUC值为0.776(95%CI:0.703~0.849,P<0.001),其灵敏度为85.6%,特异度为65.3%。结论:血清CA125可作为肺结核的重要鉴别诊断指标,联合检测CEA,CA125及CA199可明显提高肺结核诊断的灵敏度。
关键词: 肺结核;癌胚抗原;糖类抗原125;糖类抗原199

Value of serum CEA, CA125, and CA199 in diagnosis of pulmonary tuberculosis

Authors: 1ZHANG Ting, 1WANG Yanan, 1MIAO Qi, 1TIAN Juan
1 Department of Nuclear Medicine, The 8th Medical Center of Chinese PLA General Hospital, Beijing 100191, China

CorrespondingAuthor: ZHANG Ting Email: zhangting618@126.com

DOI: 10.3978/j.issn.2095-6959.2020.08.017

Abstract

Objective: To investigate the changes of serum tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199) in patients with pulmonary tuberculosis and their clinical value. Methods: A total of 112 patients with pulmonary tuberculosis (pulmonary tuberculosis), 30 patients with lung cancer (the lung cancer group) and 30 healthy subjects (the control group) were selected. The serum tumor markers CEA, CA125 and CA199 were detected and compared. The diagnostic value of three tumor markers in tuberculosis were analyzed. Results: The levels of serum CEA, CA125 and CA199 in each group were significantly different (all P<0.05). The levels of serum CEA and CA199 in lung cancer group were significantly higher than those in tuberculosis group and control group (all P<0.05). The serum CA125 level in tuberculosis group was significantly higher than that in lung cancer group and control group (all P<0.01); the level of CA199 in lung cancer group was significantly higher than that in the control group (all P<0.05). The area under the ROC curve (AUC) of serum CA125 was 0.745 (95% CI: 0.711 to 0.861, P<0.001) with a sensitivity of 81.8% and a specificity of 62.3%. The combined detection of each tumor marker showed an AUC value of 0.776 (95% CI: 0.703 to 0.849, P<0.001) with a sensitivity of 85.6% and a specificity of 65.3%. Conclusion: Serum CA125 can be used as an important differential diagnosis index for tuberculosis. Combined detection of CEA, CA125 and CA199 can significantly improve the sensitivity of tuberculosis diagnosis.
Keywords: pulmonary tuberculosis; carcinoembryonic antigen; carbohydrate antigen 125; carbohydrate antigen 199