1 涿州市医院呼吸内科，河北 涿州 072750
目的：分析慢性阻塞性肺疾病(chronic obstructive pulmonary diseases，COPD)合并反流性食管炎(reflux esophagitis，RE)患者的疾病恢复和预后特点和应对措施。方法：纳入2015年12月至2017年5月涿州市医院收诊的合并RE的COPD患者130例，并对其临床资料进行回顾性分析，其中对照组仅接受常规的COPD恢复应对措施(n=48)，实验组接受COPD合并RE治疗(n=82)，对患者的病症特点进行比较，观察应对措施的效果。结果：在未接受治疗前，对照组患者的肺功能指标[用力肺活量(forced vital capacity，FVC)、1 s用力呼气容积(forced expiratory volume in one second，FEV1)]均与实验组患者的差异无统计学意义(P>0.05)。在实验结束时，对照组患者的肺功能指标较治疗前略有下滑，差异无统计学意义(P>0.05)；实验组肺功能指标明显上升，但与治疗前的差异无统计学意义(P>0.05)，与对照组的差异有统计学意义(P<0.05)；根据Wolf和Lazar分度法，治疗前对照组病症在1~3级的患者为30例(30/48，62.50%)，治疗后为38例(38/48，79.17%)，实验组治疗前52例(63.41%)，治疗后14例(17.07%)，治疗前差异无统计学意义(P>0.05)，治疗后差异有统计学意义(P<0.05)。实验组患者的年住院次数、年住院总天数均占据明显的优势，差异有统计学意义(P<0.05)。结论：临床上对COPD合并RE患者采取针对性的治疗措施能够有效地改善患者的肺功能，减轻胃酸对于食管的影响以及相应并发症的损伤，进而减少患者的住院时间、住院次数。
Response measures and prognostic characteristics of disease recovery of chronic obstructive pulmonary diseases with reflux esophagitis patients
CorrespondingAuthor: WANG Meiling
This work was supported by Baoding Science and Technology Plan Project, China (18ZF106).
Objective: To analyze the characteristics of disease recovery and prognosis of chronic obstructive pulmonary diseases (COPD) patients with reflux esophagitis (RE) and the countermeasures. Methods: From December 2015 to May 2017, 130 COPD patients with reflux esophagitis in Zhuozhou City Hospital were analyzed retrospectively. The control group only received conventional recovery response measures for COPD (n=48), and the experimental group received COPD combined with RE treatment (n=82). The symptoms and symptoms of the patients were compared, and the effect of the response measures was observed. Results: Before the treatment, the lung function indexes (FVC, FEV1) in the control group were slightly different from those in the experimental group, and the differences were not statistically significant (P>0.05), but the statistical values at the end of the experiment showed that the lung function indexes in the control group were slightly lower than those before the treatment, but the differences were small, and the differences were not statistically significant (P>0.05), In the experimental group, the lung function index increased significantly, but there was no significant difference between the experimental group and the control group (P>0.05). According to Wolf and Lazar Classification method, 30 patients in the control group were 1–3 grade before treatment, 38 patients after treatment, the probability was 62.5% (30/48) and 79.17% (38/48) respectively, the experimental group was 63.41% (52/82) and 17.07% (14/82) respectively, the difference before treatment was not statistically significant (P>0.05), the difference after treatment was significant (P<0.05), the whole experimental period; The number of hospitalization and the total days of hospitalization in the experimental group were significantly higher than those in the control group (P<0.05). Conclusion: the patients with COPD and re need to take targeted treatment measures, which can effectively improve the lung function of patients, reduce the impact of gastric acid on the esophagus and the corresponding complications, and then reduce the length of stay and the number of hospital stay of patients.
chronic obstructive pulmonary disease; reflux esophagitis; disease recovery; lung function; response measures