文章摘要

蛇毒血凝酶联合垂体后叶素在经支气管动脉栓塞治疗咯血中的作用

作者: 1蒲波
1 重庆三峡中心医院呼吸与危重症医学科,重庆 404000
通讯: 蒲波 Email: 147561805@163.com
DOI: 10.3978/j.issn.2095-6959.2020.08.022

摘要

目的:观察蛇毒血凝酶联合垂体后叶素在经支气管动脉栓塞治疗的咯血患者中的作用。方法:选取2017年5月至2019年12月收治的120例经支气管动脉栓塞治疗的咯血患者按随机数表法分成观察组和对照组,每组各60例。对照组给予垂体后叶素静脉滴注,观察组在对照组的基础上给予蛇毒血凝酶。对比两组治疗效果、凝血功能及治疗安全性。结果:观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);两组治疗前凝血酶原时间(prothrombin time,PT),活化部分凝血活酶时间(activated partial thromboplastin time,APTT),凝血酶时间(thrombin time,TT)水平比较,差异无统计学意义(P>0.05);两组治疗后PT,APTT,TT水平明显低于治疗前,差异均有统计学意义(均P<0.05);观察组治疗后PT,APTT,TT水平明显低于对照组,差异均有统计学意义(均P<0.05);观察组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:蛇毒血凝酶联合垂体后叶素能有效提高经支气管动脉栓塞治疗的咯血患者的治疗效果,且安全性较高。
关键词: 蛇毒血凝酶;垂体后叶素;支气管动脉栓塞术;气管扩张咯血

Role of venomous hemocoagulase combined with pituitrin in patients with hemoptysis treated with tracheal artery embolization

Authors: 1PU Bo
1 Department of Respiratory and Critical Care Medicine, Chongqing Three Gorges Central Hospital, Chongqing 404000, China

CorrespondingAuthor: PU Bo Email: 147561805@163.com

DOI: 10.3978/j.issn.2095-6959.2020.08.022

Abstract

Objective: To observe the role of venomous hemocoagulase combined with pituitrin in patients with hemoptysis treated with transcatheter arterial embolization. Methods: From May 2017 to December 2019, 120 patients with hemoptysis treated by bronchial artery embolization were divided into an observation group and a control group according to random digital table method (n=60 for each group). The control group was given intravenous drip of pituitary, and the observation group was given snake venom hemocoagulase on the basis of the control group. The therapeutic effect, coagulation function, and safety of the 2 groups were compared. Results: The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). There was no significant difference in the levels of prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) between the two groups before treatment (all P>0.05). The levels of PT, APTT, and TT in the 2 groups were significantly lower than those before treatment (all P<0.05). The levels of PT, APTT, and TT in the observation group were significantly lower than those in the control group (all P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Venomous hemocoagulase combined with pituitary hindleaf can effectively improve the efficacy of hemoptysis patients treated by transbronchial embolization, and reduce the recurrence rate with high safety.
Keywords: venomous hemocoagulase; pituitrin; bronchial artery embolization; tracheal dilatation