文章摘要

老年反复呼吸道感染产ESBLs细菌调查及耐药性分析

作者: 1于群, 2黄伟英, 3李晓明
1 青岛市第九人民医院门诊部,青岛 266002
2 青岛市第九人民医院供应室,青岛 266002
3 青岛市第九人民医院消化内科,青岛 266002
通讯: 李晓明 Email: yuqun91@163.com
DOI: 10.3978/j.issn.2095-6959.2020.08.023

摘要

目的:研究老年人群(>60岁)反复呼吸道感染(recurrent respiratory tract infection,RRTI)产ESBLs细菌调查及耐药情况,为老年人群RRTI的防治提供临床指导。方法:统计分析2018年1月至2019年1月青岛市第九人民医院老年RRTI患者ESBLs细菌感染发生情况及其耐药性。结果:384例RRTI老年患者共分离124株肺炎克雷伯菌及76株大肠埃希菌。产ESBLs总检出率为40.50%(81/200),其中肺炎克雷伯菌产ESBLs检出率48.39%(60/124),大肠埃希菌产ESBLs检出率27.63%(21/76);老年 RRTI细菌培养产ESBLs菌株对氨苄西林、头孢噻肟、头孢他啶、庆大霉素、左氧氟沙星、环丙沙星、复方新诺明、阿米卡星、哌拉西林耐药率均超过50%,非产ESBLs菌株耐药率均低于50%,产ESBLs菌株对氨苄西林、头孢噻肟、头孢他啶、头孢吡肟、庆大霉素、左氧氟沙星、环丙沙星、复方新诺明、哌拉西林耐药率均高于非产ESBLs菌株,差异有统计学意义(P<0.05)。结论:了解老年人群RRTI产ESBLs细菌发生情况及耐药性有助于指导临床抗生素的合理使用,提高老年人群RRTI的治疗效果。
关键词: 老年人群;反复呼吸道感染;产ESBLs细菌;耐药

Investigation on the ESBLs bacteria and analysis of drug resistance in elderly patients with recurrent respiratory tract infection

Authors: 1YU Qun, 2HUANG Weiying, 3LI Xiaoming
1 Outpatient Department, Qingdao Ninth People’s Hospital, Qingdao 266002, China
2 Supply Room, Qingdao Ninth People’s Hospital, Qingdao 266002, China
3 Department of Gastroenterology, Qingdao Ninth People’s Hospital, Qingdao 266002, China

CorrespondingAuthor: LI Xiaoming Email: yuqun91@163.com

DOI: 10.3978/j.issn.2095-6959.2020.08.023

Abstract

Objective: To investigate the ESBLs producing bacteria and their resistance in the elderly (>60 years old) with recurrent respiratory tract infection, and to provide clinical guidance for the prevention and treatment of recurrent respiratory tract infection in the elderly. Methods: From January 2018 to January 2019, the incidence of ESBLs bacterial infection in elderly patients with recurrent respiratory tract infection was analyzed. Results: A total of 124 strains of Klebsiella pneumoniae and 76 strains of Escherichia coli were isolated from 384 elderly patients with recurrent respiratory tract infection. The total detection rate of ESBLs was 40.50% (81/200), of which 48.39% (60/124) was from Klebsiella pneumoniae and 27.63% (21/76) was from Escherichia coli. The ESBLs strains from bacterial culture of elderly patients with recurrent respiratory tract infection were ampicillin, cefotaxime, ceftazidime, gentamicin, levofloxacin, ciprofloxacin, compound xinuoming and amikacin The resistance rate of ESBLs producing strains to ampicillin, cefotaxime, ceftazidime, cefepime, gentamycin, levofloxacin, ciprofloxacin, compound minophen and piperacillin was higher than that of non ESBLs producing strains (P<0.05). Conclusion: to understand the occurrence of ESBLs producing bacteria in elderly patients with recurrent respiratory tract infection and their drug resistance is helpful to guide the rational use of antibiotics and improve the therapeutic effect of elderly patients with recurrent respiratory tract infection.
Keywords: elderly people; recurrent respiratory tract infection; ESBLs producing bacteria; drug resistance