文章摘要

视野和图形视诱发电位对非动脉炎性前部缺血性视神经病变患者视功能的评估价值

作者: 1郭金喜, 1赵云, 1路璐
1 河北省眼科医院特检科,河北 邢台 054001
通讯: 郭金喜 Email: qqqchao123123@163.com
DOI: 10.3978/j.issn.2095-6959.2020.08.027
基金: 邢台市科技支撑计划项目(2016ZC078)。

摘要

目的:探讨视野和图形视诱发电位(pattern visual evoked potential,PVEP)对非动脉炎性前部缺血性视神经病变(nonarteritic anterior ischemic opticneuropathy,NAION)患者视功能的评估价值。方法:回顾分析2017年3月至2020年3月河北省眼科医院收治的NAION患者122例154只眼临床资料作为疾病组,根据最佳矫正视力评估疾病组患者视功能,将其划分为轻度组(0.8≥最佳矫正视力>0.3,95只眼)、重度组(0.3≥最佳矫正视力,59只眼),另外选择无眼部疾病的健康者70例140只眼为对照组。比较对照组和疾病组视野、PVEP情况,利用受试者操作特征(receiver operating characteristic,ROC)曲线评估视野、PVEP对NAION患者视功能的评估价值。结果:疾病组视野平均缺损、P100潜伏期高于对照组,视野平均敏感度、P100振幅低于对照组,差异均有统计学意义(均P<0.05);视功能重度组视野平均缺损、P100潜伏期高于轻度组,视野平均敏感度、P100振幅低于轻度组,差异均有统计学意义(均P<0.05);ROC曲线分析显示:视野平均敏感度、平均缺损、P100潜伏期和P100振幅预测NAION患者出现严重视功能障碍的曲线下面积分别为0.827,0.809,0.775及0.896,四者均对NAION患者视功能具有一定的预测价值。结论:与健康者相比,NAION患者视野平均敏感度、P100振幅更低,视野平均缺损、P100潜伏时更高,视野、PVEP指标对预测NAION患者视功能损害程度具有一定实用价值。
关键词: 前部缺血性视神经病变;视野;图形视诱发电位;视功能

Evaluation value of visual field and pattern visual evoked potential in visual function of patients with non-arteritis anterior ischemic optic neuropathy

Authors: 1GUO Jinxi, 1ZHAO Yun, 1LU Lu
1 Department of Special Inspection, Hebei Eye Hospital, Xingtai Hebei 054001, China

CorrespondingAuthor: GUO Jinxi Email: qqqchao123123@163.com

DOI: 10.3978/j.issn.2095-6959.2020.08.027

Foundation: This work was supported by the Xingtai Science and Technology Support Plan Project, China (2016zc078).

Abstract

Objective: To explore the evaluation value of visual field and pattern visual evoked potential (PVEP) in visual function of patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods: The clinical data of 122 NAION patients (154 eyes, disease group) who were admitted to Hebei Eye Hospital from March 2017 to March 2020 were retrospectively analyzed. According to the best corrected visual acuity (BCVA), the visual function in the disease group was evaluated. And they were divided into a mild group (0.8≥ BCVA >0.3, 95 eyes) and a severe group (0.3≥ BCVA, 59 eyes). Seventy healthy people (140 eyes) without eye diseases were enrolled as a control group. The visual field and PVEP were compared between the control group and the disease group. The evaluation value of visual field and PVEP in the visual function of NAION patients was assessed by receiver operating characteristic (ROC) curves. Results: The average defects of visual field and P100 latency in the disease group were higher than those in the control group, while and average sensitivity of visual field and P100 amplitude were lower than those in the control group (all P<0.05). The average defects of visual field and P100 latency in visual function severe abnormality group were higher than those in the mild group, while the average sensitivity of visual field and P100 amplitude were lower than those in the mild group (all P<0.05). ROC curve analysis showed that the area under curve values of average sensitivity and average defects of visual field, P100 latency and P100 amplitude for predicting severe visual dysfunction in NAION patients were 0.827, 0.809, 0.775, and 0.896, which all were of certain predictive value for the visual function of NAION patients. Conclusion: Compared with healthy people, average sensitivity of visual field and P100 amplitude are lower, while average defects of visual field and P100 latency are higher in NAION patients. Visual field and PVEP indexes are of certain practical value for predicting visual impairment degree of NAION patients.
Keywords: anterior ischemic opticneuropathy; visual field; pattern visual evoked potential; visual function