文章摘要

缺氧诱导因子对肿瘤的影响及其对胃肠道间质瘤的作用

作者: 1黄欣欣, 1黄婷, 2杨贤, 2白淘
1 山西医科大学第一临床医学院,太原 030001
2 山西医科大学第一医院病理科,太原 030001
通讯: 白淘 Email: 13703515398@163.com
DOI: 10.3978/j.issn.2095-6959.2020.08.043
基金: 山西省卫生健康委员会科研课题(2017035);山西省科技厅面上项目(201801D121331)。

摘要

在缺氧环境下,细胞为作出适应性反应而产生了缺氧诱导因子(hypoxia-inducible factors,HIFs)。HIF不仅是细胞适应低氧和营养缺乏环境的主要调控因子,还是促进许多肿瘤发展的重要转录因子。HIF可在代谢、转移、耐药等多方面调节靶基因的活性,进而影响肿瘤的进展,对患者的预后产生较大影响。HIF的破坏可以直接抑制肿瘤细胞的增殖。目前,HIF已成为新型抗肿瘤药物的作用靶点。有研究表明,HIF参与了部分类型胃肠道间质瘤的发病。HIF与胃肠道间质瘤(gastrointestinal stromal tumors,GIST)之间的关系值得被深入研究。
关键词: 缺氧诱导因子;肿瘤;胃肠道间质瘤;靶基因

Effect of hypoxia-inducible factors on tumors and its role in gastrointestinal stromal tumors

Authors: 1HUANG Xinxin, 1HUANG Ting, 2YANG Xian, 2BAI Tao
1 First Clinical Medical College, First Hospital, Shanxi Medical University, Taiyuan 030001, China
2 Department of Pathology, First Hospital, Shanxi Medical University, Taiyuan 030001, China

CorrespondingAuthor: BAI Tao Email: 13703515398@163.com

DOI: 10.3978/j.issn.2095-6959.2020.08.043

Foundation: This work was supported by Shanxi Provincial Health and Health Committee Research Project (2017035) and Shanxi Provincial Science and Technology Department Project (201801D121331), China.

Abstract

Hypoxia-inducible factors (HIFs) are produced by cells in response to hypoxia. HIF is not only a major regulator of cell adaptation to hypoxic and nutrient-deficient environments, but also an important transcription factor that promotes the development of many tumors. HIF can regulate the activity of target genes in many aspects such as metabolism, metastasis, and drug resistance, which in turn affects the progression of tumors and has a greater impact on the prognosis of patients. The disruption of HIF can directly inhibits the proliferation of tumor cells. At present, HIF has become a target for new anti-tumor drugs. Current studies have shown that HIF is involved in the pathogenesis of some types of gastrointestinal stromal tumors. The study of the relationship between HIF and gastrointestinal stromal tumors (GIST) is worthy of further exploration.
Keywords: hypoxia-inducible factors; tumor; gastrointestinal stromal tumors; target gene