文章摘要

影响上消化道出血的相关危险因素

作者: 1袁玥, 1郝建宇, 1刘心娟
1 首都医科大学附属北京朝阳医院消化内科,北京100020
通讯: 刘心娟 Email: lxjw2012@126.com
DOI: 10.3978/j.issn.2095-6959.2021.07.039
基金: 首都卫生发展科研专项项目(首发2020-2-2034).

摘要

上消化道出血为内科常见急危重症之一,其因较高的发病率和病死率而在全球范围内受到广泛关注。本文对上消化道出血的相关危险因素进行总结,发现年龄、性别、幽门螺杆菌感染、慢性肾功能不全、心功能不全应用左室辅助装置、长期单独或联合应用非甾体类抗炎药(non-steroid anti-inflammatory drugs,NSAIDs)、选择性5-羟色胺再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)等药物、气象因素和吸烟饮酒等不良生活习惯为发病的危险因素。VKORC基因多态性等其他可能的危险因素还需进一步研究。明确上消化道出血的危险因素,可优化相关高危人群的管理及治疗策略,有效预防上消化道出血的发生,对提高患者生活质量、节约卫生经费具有重要意义。
关键词: 上消化道出血;危险因素;非甾体类抗炎药

Related risk factors for upper gastrointestinal bleeding

Authors: 1YUAN Yue, 1HAO Jianyu, 1LIU Xinjuan
1 Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

CorrespondingAuthor: LIU Xinjuan Email: lxjw2012@126.com

DOI: 10.3978/j.issn.2095-6959.2021.07.039

Foundation: This work was supported by Capital’s Funds for Health Improvement and Research, China (2020-2-2034).

Abstract

Upper gastrointestinal bleeding (UGIB) is one of the most common acute and critical diseases in internal medicine. With a considerable morbidity and mortality, it has become a global concern. This article summarized the related risk factors for UGIB. We found that age, gender, Helicobacter pylori (H. pylori) infection, chronic renal insufficiency, cardiac insufficiency with continuous-flow left ventricular assist devices, long-term use of non-steroid anti-inflammatory drugs (NSAIDs) and selective serotonin reuptake inhibitors (SSRIs) alone or in combination, meteorological factors, and unhealthy lifestyle such as smoking and alcohol consumption were risk factors of UGIB. Other possible factors like VKORC polymorphism need further studying. Clarifying risk factors of UGIB will definitely aid in optimizing its monitoring, improving therapeutic strategies, and effectively preventing recurrence, which eventually improves life quality and lowers financial burden.
Keywords: upper gastrointestinal bleeding; risk factors; non-steroid anti-inflammatory drugs