文章摘要

血脂在急性胰腺炎病情判断中作用的研究进展

作者: 1周锋, 1王林, 1闫昌盛, 1刘冬晓, 1王拥卫, 1吴祥松
1 哈尔滨医科大学附属第一医院胰胆外科,哈尔滨 150001
通讯: 吴祥松 Email: 13633621389@163.com
DOI: 10.3978/j.issn.2095-6959.2021.06.031
基金: 国家自然科学基金(81702384);黑龙江省教育厅科学技术研究项目(12541498);黑龙江省科技计划(LCO8C25)。

摘要

急性胰腺炎(acute pancreatitis,AP)是一种常见且严重的消化系统疾病,表现为胰腺的突发性炎症,为自限性过程,通过系统治疗预后良好。20%的患者病情严重,伴有致命并发症,预后较差,称为重症急性胰腺炎(severe acute pancreatitis,SAP)。SAP患者病死率高,为35%~50%。早期识别SAP有助于临床医师早期及时实施有效的治疗方案,如早期ICU或外科干预,或其他差异性治疗等,从而最大限度地降低并发症的发生率和SAP的病死率,因此对AP病情的判断及SAP的早期预测是治疗AP的一个重要方面。有研究发现,血清脂质变化与AP病情相关,本文就血脂变化与急性胰腺炎病情严重程度作一综述,旨在通过血脂变化为早期诊断SAP提供帮助。
关键词: 急性胰腺炎;血脂;严重程度;早期预测

Research progress on the role of blood lipids in the judgment of acute pancreatitis

Authors: 1ZHOU Feng, 1WANG Lin, 1YAN Changsheng, 1LIU Dongxiao, 1WANG Yongwei, 1WU Xiangsong
1 Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: WU Xiangsong Email: 13633621389@163.com

DOI: 10.3978/j.issn.2095-6959.2021.06.031

Foundation: This work was supported by National Natural Science Foundation (81702384), the Science and Technology Research Project of Heilongjiang Provincial Education Department (12541498), and the Science and Technology Plan of Heilongjiang Province (LCO8C25), China.

Abstract

Acute pancreatitis (AP) is a common and serious digestive system disease characterized by sudden inflammation of the pancreas, and most acute pancreatitides are self-limited processes. The prognosis is good through systematic treatment. There are still 20% patients with severe and fatal complications with poor prognosis called severe acute pancreatitis (SAP). SAP patients have a high mortality rate, ranging from 35% to 50%. Early recognition of SAP patients can help clinicians start effective treatment early and timely, such as early ICU or surgical intervention, or other differential treatments, thereby minimizing the incidence of complications and mortality. Therefore, the judgment of AP condition and the early prediction of SAP are important in the treatment of AP. Some studies have found that changes in blood lipids are related to the condition of AP. This article reviews the changes in blood lipids and the condition of acute pancreatitis, and aims to provide early diagnosis of SAP through blood lipids.
Keywords: acute pancreatitis; blood lipids; severity; early prediction