文章摘要

MiRNA在结直肠癌干细胞信号通路中的作用

作者: 1陈悦华, 1戚基萍
1 哈尔滨医科大学附属第一医院病理科,哈尔滨 150001
通讯: 戚基萍 Email: qijiping2003@163.com
DOI: 10.3978/j.issn.2095-6959.2021.06.024

摘要

MiRNA是一类内源性非编码的单链小RNA,可以通过调控结直肠癌干细胞(colorectal cancer stem cell,CCSC)等参与结直肠癌(colorectal cancer,CRC)发生发展的各种过程。CCSC被认为是导致CRC发生发展、转移复发以及耐药性的主要原因,miRNA在CCSC中差异表达,并且可在CRC组织和不同体液中保持一定的特异性和稳定性,因而miRNA可作为CRC临床早期检测诊断、疗效预测及个体化治疗的新型生物标志物。
关键词: miRNA;结直肠癌干细胞;信号通路;耐药性

Role of miRNA in colorectal cancer stem cell signaling pathway

Authors: 1CHEN Yuehua, 1QI Jiping
1 Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: QI Jiping Email: qijiping2003@163.com

DOI: 10.3978/j.issn.2095-6959.2021.06.024

Abstract

miRNA is a group of endogenous non-coding single-stranded small RNAs that can regulate various processes of colorectal cancer (CRC) development, including colorectal cancer stem cells (CCSC). CCSC are considered to be the main cause of the development, metastasis, recurrence and drug resistance of CRC. miRNA is differentially expressed in CCSC and can maintain its specificity and stability in CRC tissues and body fluids. Therefore, miRNA can be used as a new biomarker for the early clinical detection and diagnosis of CRC, prediction of therapy and individualized treatment.
Keywords: miRNA; colorectal cancer stem cells; signaling pathways; drug resistance