文章摘要

MicroRNA与IgA肾病的研究进展

作者: 1,2,3兰竞超, 1,2,3沈颖
1 首都医科大学附属北京儿童医院肾内科,北京 100045
2 首都医科大学附属北京儿童医院儿童慢性肾脏病与血液净化北京市重点实验室,北京 100045
3 首都医科大学附属北京儿童医院儿科重大疾病研究教育部重点实验室,北京 100045
通讯: 沈颖 Email: shenying@bch.com.cn
DOI: 10.3978/j.issn.2095-6959.2021.06.025
基金: 国家自然科学基金 (81600551)。

摘要

IgA肾病发病机制复杂,尚未完全了解。一些microRNA(miRNA)在IgA肾病患者中出现差异性的表达,提示可能参与IgA肾病的发病机制,作为新的非创伤性生物标志物,miRNA为诊断、预防以及改善IgA肾病预后提供了新的研究方向。
关键词: IgA肾病;microRNA;无创性生物标志物

Research progress in microRNA and IgA nephropathy

Authors: 1,2,3LAN Jingchao, 1,2,3SHEN Ying
1 Department of Nephrology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
2 Beijing Key Laboratory of Chronic Kidney Disease and Blood Purification in Childhood, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
3 Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China

CorrespondingAuthor: SHEN Ying Email: shenying@bch.com.cn

DOI: 10.3978/j.issn.2095-6959.2021.06.025

Foundation: This work was supported by National Natural Science Fund of China (81600551).

Abstract

The pathogenesis of IgA nephropathy is complex and has not been fully understood. Some microRNAs (miRNAs) are differentially expressed in patients with IgA nephropathy, suggesting that miRNA may be involved in the pathogenesis of IgA nephropathy. As a new non-invasive biomarker, miRNA provides a new research direction for the diagnosis, prevention and improvement of the prognosis of IgA nephropathy. This paper reviews the literatures about the relationship between IgA nephropathy and some miRNAs at home and abroad.
Keywords: IgA nephropathy; microRNA; non-invasive biomarker