文章摘要

磷酸酶与张力蛋白同源物在多种疾病中的研究进展

作者: 1王思雨, 1郝丽荣
1 哈尔滨医科大学附属第一医院肾内科,哈尔滨 150000
通讯: 郝丽荣 Email: hao_lirong@163.com
DOI: 10.3978/j.issn.2095-6959.2021.06.030
基金: 国家自然科学基金(81870503)。

摘要

磷酸酶与张力蛋白同源物(PTEN)基因,又称MMAC1或TEP1,为1997年发现的抑癌基因,属于PTP(protein tyrosine phosphatases)基因家族成员。PTEN具有脂质磷酸酶和蛋白磷酸酶活性,其底物是磷脂酰肌醇(3,4,5)-三磷酸(PIP3)。研究发现:PTEN可以通过去磷酸化PIP3调节下游效应分子及信号通路,如AKT/PKB激酶、PI3K/AKT/MTOR信号通路等。PTEN具有广泛的生物学特性,参与肿瘤、心血管疾病、肾脏疾病、纤维化和神经系统疾病、自身免疫病的发生及发展,在多种疾病中起重要作用。
关键词: 磷酸酶与张力蛋白同源物;肿瘤;心血管疾病;肾脏疾病

Research progress of PTEN in various diseases

Authors: 1WANG Siyu, 1HAO Lirong
1 Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China

CorrespondingAuthor: HAO Lirong Email: hao_lirong@163.com

DOI: 10.3978/j.issn.2095-6959.2021.06.030

Foundation: This work was supported by National Natural Science Foundation of China (81870503).

Abstract

Phosphatase and tensin homolog (PTEN) gene, also known as MMAC1 or TEP1, is a tumor suppressor gene discovered in 1997 and belongs to the family of PTP (protein tyrosine phosphatases). PTEN has the activity of lipid phosphatase and protein phosphatase, and its substrate is phosphatidylinositol (3,4,5)-triphosphate (PIP3).The study found that PTEN can regulate downstream effector molecules and signaling pathways, such as Akt/PKB kinase, PI3K/Akt/mTOR signaling pathways, by dephosphorylating PIP3. PTEN has a wide range of biological characteristics, and plays an important role in the occurrence and development of tumor, cardiovascular disease, kidney disease, fibrosis, nervous system disease and autoimmune disease.
Keywords: phosphatase and tensin homolog; tumor; cardiovascular disease; kidney disease