文章摘要

乳酸/HCAR1信号系统的生物学功能研究进展

作者: 1帅念念, 1周佳秀, 2田绍文, 1王波, 1,3旷昕
1 南华大学附属第一医院麻醉科,湖南 衡阳 421001
2 桂林医学院基础医学院广西脑与认知神经科学重点实验室,广西 桂林 541001
3 南方医科大学附属龙华区人民医院麻醉科,广东 深圳 518109
通讯: 旷昕 Email: kx6924@126.com
DOI: 10.3978/j.issn.2095-6959.2021.08.032
基金: 湖南省自然科学基金(2018JJ3465)。

摘要

羟基羧酸受体1(hydroxy-carboxylic acid receptor 1,HCAR1)是一种孤儿G蛋白耦联受体,也是乳酸的特异性受体,广泛分布于中枢和外周组织。近年来,越来越多的研究表明,乳酸/HCAR1信号系统在机体发挥重要作用。乳酸/HCAR1信号系统通过激活下游信号通路,参与内分泌系统、心血管系统、神经系统、免疫系统、肿瘤等相关系统疾病的发生和发展过程。
关键词: 乳酸;羟基羧酸受体1;GPR81;内分泌系统;神经系统;肿瘤

Research progress in the biological function of lactate/HCAR1 signaling system

Authors: 1SHUAI Niannian, 1ZHOU Jiaxiu, 2TIAN Shaowen, 1WANG Bo, 1,3KUANG Xin
1 Department of Anesthesiology, First Affiliated Hospital of University of South China, Hengyang Hunan 421001, China
2 Guangxi Key Laboratory of Brain and Congnitive Neuroscience, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin Guangxi 541001, China
3 Department of Anesthesiology, Longhua People’s Hospital, Southern Medical University, Shenzhen Guangdong 518109, China

CorrespondingAuthor: KUANG Xin Email: kx6924@126.com

DOI: 10.3978/j.issn.2095-6959.2021.08.032

Foundation: This work was supported by the Hunan Provincial Natural Science Foundation, China (2018JJ3465).

Abstract

Hydroxy-carboxylic acid receptor 1 (HCAR1) is an orphan G protein-coupled receptor and a specific receptor for lactate, which is widely distributed in central and peripheral tissues. In recent years, more and more studies have shown that lactate/HCAR1 signaling system plays an important role in the body. By activating the downstream signaling pathway, the lactate/HCAR1 signaling system is involved in the occurrence and development of diseases related to endocrine system, cardiovascular system, nervous system, immune system, tumors, etc.
Keywords: lactate; hydroxy-carboxylic acid receptor 1; GPR81; endocrine system; nervous system; tumors