文章摘要

Artemin在恶性肿瘤转移中的研究进展

作者: 1朱梦景, 1周怀君
1 南京医科大学鼓楼临床医学院妇科,南京 210008
通讯: 周怀君 Email: zhouhj2007@126.com
DOI: 10.3978/j.issn.2095-6959.2021.06.023
基金: 国家自然科学基金(81972434)。

摘要

恶性肿瘤是危害人类健康的一大难题,转移是导致恶性肿瘤具有难治性和致死性的关键因素。Artemin(ARTN)是胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)配体家族(GDNF-family ligands,GFLs)中的一员,其信号转导主要通过与共受体GFRα3-RET结合,形成一个信号复合物调节细胞内信号转导,影响神经系统发育和细胞内稳态。近年来,多项研究表明Artemin在呼吸系统肿瘤、消化系统肿瘤等多种恶性肿瘤中具有促进肿瘤细胞侵袭和转移的作用,与肿瘤的复发转移及预后密切相关。
关键词: Artemin;恶性肿瘤;转移

Emerging insights into the metastatic role of Artemin in malignant tumors

Authors: 1ZHU Mengjing, 1ZHOU Huaijun
1 Department of Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

CorrespondingAuthor: ZHOU Huaijun Email: zhouhj2007@126.com

DOI: 10.3978/j.issn.2095-6959.2021.06.023

Foundation: This work was supported by the National Natural Science Foundation of China (81972434).

Abstract

Malignant tumor has become a serious problem that threatens human health, and tumor metastasis is one of the key factors leading to disease obstinacy and death. Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family of ligands (GFLs), and the signaling transduction is mainly through the combination with the co-receptor GFRα3-RET to form a signal complex that regulates intracellular signal transduction and affect the development of the nervous system and cell homeostasis. In recent years, a number of studies have shown that Artemin can promote the invasion and metastasis of tumor cells in a variety of malignant tumors such as respiratory system tumors and digestive system tumors, and is closely related to tumor recurrence, metastasis and prognosis.
Keywords: Artemin; malignant tumors; metastasis