文章摘要

脑源性神经营养因子与肿瘤的相关性

作者: 1巨春雷, 2胡昌辰, 2陈胜利
1 山西医科大学,太原 030000
2 山西医科大学附属人民医院神经外科,太原 030000
通讯: 陈胜利 Email: shenglic@163.com
DOI: 10.3978/j.issn.2095-6959.2022.04.031
基金: 国家自然科学基金(30901774);山西省重点研发计划项目(国际合作)(201803D421055)。

摘要

近年来,由于肿瘤的发病率和病死率逐渐升高,关于肿瘤病因学的研究也不断深入。脑源性神经 营养因子(brain-derived neurotrophic factor,BDNF)作为神经营养因子超家族中的一员,目前已被 证明与多种疾病的发生、发展相关,BDNF与酪氨酸激酶受体B(tyrosine kinase B,TrkB)结合后可 通过促进肿瘤血管、神经生成,诱导肿瘤细胞上皮间质转换等途径,在肿瘤的转移、侵袭及耐药 性的产生中发挥重要作用。
关键词: 脑源性神经营养因子;肿瘤;微RNA;长链非编码RNA

Correlation between brain-derived neurotrophic factor and tumor

Authors: 1JU Chunlei, 2HU Changchen, 2CHEN Shengli
1 Shanxi Medical University, Taiyuan 030000, China
2 Department of Neurosurgery, People’s Hospital Affiliated to Shanxi Medical University, Taiyuan 030000, China

CorrespondingAuthor: CHEN Shengli Email: shenglic@163.com

DOI: 10.3978/j.issn.2095-6959.2022.04.031

Foundation: This work was supported by the National Natural Science Foundation (30901774) and Shanxi Provincial Key Research and Development Program (201803D421055), China.

Abstract

In recent years, incidence rate and mortality rate of cancer have been increasing. As a member of the neurotrophic factor superfamily, brain-derived neurotrophic factor (BDNF) has been proved to be associated with the occurrence and development of many diseases, among them, the binding of BDNF with tyrosine kinase B (TrkB) plays a key role in tumor metastasis, invasion, and drug resistance by promoting tumor angiogenesis and neurogenesis, as well as epithelial mesenchymal transition of tumor cells.
Keywords: brain-derived neurotrophic factor; tumor; microRNAs; long non-coding RNA