文章摘要

妊娠合并单增李斯特菌感染56例

作者: 1杨小青
1 北京市通州区妇幼保健院内科,北京 101101
通讯: 杨小青 Email: zhuweidong-0312@163.com
DOI: 10.3978/j.issn.2095-6959.2021.06.020

摘要

目的:探究对妊娠合并单增李斯特菌感染孕妇首发表现、治疗状况、妊娠结局与影响因素,为临床提供指导。方法:将2019年1月至12月北京市通州区妇幼保健院内科门诊56例妊娠合并单增李斯特菌感染孕妇作为主要研究对象,采用回顾性分析方法总结妊娠期单增李斯特菌感染的发病特点、表现、治疗和预后。结果:在56例孕妇中,血培养呈阳性36例,阴道分泌物培养阳性25例。首发表现以胎膜早破、先兆早产、产前发热、胎儿宫内窘迫等为主。活产分娩有36例,活产分娩率为64.29%。足月10例,早产26例。胎死宫内16例,其中4例为流产。在36例活产分娩新生儿中,6例孕妇在抗感染治疗足月分娩。30例被感染新生儿,治愈/好转10例,5例死亡,15例放弃治疗。结论:妊娠合并李斯特菌感染会使早产概率明显提高,致使死胎或者是流产,具有较高的母婴共患概率。因此,如果孕产妇出现发热、胎儿宫内窘迫或者是先兆流产的情况,需警惕李斯特菌感染,以免对妊娠结局与新生儿预后带来负面影响。
关键词: 妊娠;单增李斯特菌;感染

Listeria monocytogenes infection in 56 pregnant women

Authors: 1YANG Xiaoqing
1 Department of Internal Medicine, Tongzhou Maternal, Chind Health Hospital of Beijing, Beijing 101101, China

CorrespondingAuthor: YANG Xiaoqing Email: zhuweidong-0312@163.com

DOI: 10.3978/j.issn.2095-6959.2021.06.020

Abstract

Objective: To investigate the first manifestation, treatment status, and pregnancy outcome of pregnant women with Listeria monocytogenes infection and to provide clinical guidance. Methods: A total of 56 pregnant women with Listeria monocytogenes infection were selected from January to December 2019. The characteristics, manifestations, treatment and prognosis of Listeria monocytogenes infection during pregnancy were summarized by retrospective analysis. Results: Of the 56 pregnant women, blood culture was positive in 36 cases, vaginal secretion culture was positive in 25 cases. The first manifestations were prenatal premature rupture of membranes, threatened premature delivery, prenatal fever, fetal distress and so on. Of the 56 pregnant women, 36 live births, the rate of live births was 64.29% (36/56). Ten cases were full term and 26 cases were premature delivery. Of the 16 cases of fetal death, 4 were miscarried. Of the 36 live births, 6 pregnant women gave birth in term of anti-infective therapy. Of the 30 infected newborns, 10 cases were cured/improved, 5 deaths, 15 patients gave up treatment. Conclusion: Pregnancy with Listeria infection can significantly increase the risk of premature delivery, causing a still birth or miscarriage, a higher risk of maternal and child co-infection. Therefore, if the pregnant woman has fever, fetal distress or threatened abortion, we need to watch out for Listeria infection, in order to avoid adverse effects on pregnancy outcome and neonatal prognosis.
Keywords: pregnancy; Listeria monocytogenes; infection