文章摘要

CD64指数在血液病合并感染中的研究进展

作者: 1,2,3齐林, 4王亚丽, 1张金金, 1王宝艳, 2成志勇
1 保定市第一医院血液内科,河北 保定 071000
2 承德医学院,河北 承德 067000
3 石家庄市第四医院内科,石家庄 050000
4 保定市第一医院营养科,河北 保定 071000
通讯: 成志勇 Email: dzczy@163.com
DOI: 10.3978/j.issn.2095-6959.2021.06.029
基金: 河北省适用跟踪计划项目(G2018091)。

摘要

感染是血液系统疾病常见的并发症之一。由于血液系统疾病病因及治疗特点,早期感染易发展为脓毒血症,降低患者生存率。近来,CD64指数作为诊断感染的生物学指标,其临床意义已被广泛接受。中性粒细胞CD64在外源病原体或内毒素侵入后数小时表达升高,故对早期感染具有较好的敏感性和特异性,已经用于部分感染患者检测。现就CD64指数在血液系统疾病合并感染中的应用作一综述。
关键词: CD64指数;感染;血液病

Research progress of CD64 index in hematological diseases complicated with infection

Authors: 1,2,3QI Lin, 4WANG Yali, 1ZHANG Jinjin, 1WANG Baoyan, 2CHENG Zhiyong
1 Department of Hematology, Baoding No.1 Hospital, Baoding Hebei 071000, China
2 Chengde Medical University, Chengde Hebei 067000, China
3 Department of Medicine, the Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, China
4 Department of Nutriology, Baoding No.1 Hospital, Baoding Hebei 071000, China

CorrespondingAuthor: CHENG Zhiyong Email: dzczy@163.com

DOI: 10.3978/j.issn.2095-6959.2021.06.029

Foundation: This work was supported by Applicable Tracking Plan Project of Hebei Province, China (G2018091).

Abstract

Infection is one of the common complications of hematological disorders.Because of the hematologic disease etiology and treatment characteristics, early infection is prone to develop sepsis and reduce patient survival.The CD64 index, as a biological indicator for diagnosing infection in recent years, its clinical significance has been widely accepted.CD64 on neutrophils would show better sensitivity and specificity for early infection because of its elevated expression several hours after the invasion of exogenous pathogens or endotoxin, and it has been used to detect some patients with infection. The use of the CD64 index in coinfections with hematologic diseases is now reviewed.
Keywords: CD64 index; infection; hematological diseases