文章摘要

36例肺硬化性肺细胞瘤的临床病理及免疫表型

作者: 1叶建刚, 2叶郁红, 1代祖建, 2王鹏程
1 福建省福州肺科医院胸外科,福州市临床重点专科,福州 350008
2 福建医科大学附属第一医院病理科,福州 350005
通讯: 叶建刚 Email: yjgzmy@163.com
DOI: 10.3978/j.issn.2095-6959.2022.04.003
基金: 福建省卫生计生委中青年骨干人才培养项目 (2019-ZQN-61)。

摘要

目的:探讨肺硬化性肺细胞瘤(pulmonary sclerosing pneumocytoma,PSP)的临床病理及免疫表型特征。方法:收集36例符合入组要求的PSP患者的临床病理资料,分析该疾病的临床表现、影像学特点、病理学特点以及免疫表型。结果:PSP多见于中年女性,常无症状,影像学结果大多表现为边界清晰的圆形或类圆形结节。病理关键特征为肿瘤界清、2种肿瘤细胞及4种组织结构。免疫表型:两种细胞均表达TTF-1、EMA、p-AKT;表面细胞表达CK、NapsinA;间质细胞表达vimentin,部分表达ER、PR;均不表达BRAF V600E。术后随访未见复发及转移。结论:PSP的临床及影像学表现缺乏特异性,病理形态复杂多样,掌握关键形态特征及结合免疫组织化学结果有助正确诊断,预后良好。
关键词: 肺硬化性肺细胞瘤;临床病理特征;免疫表型

Clinicopathological and immunophenotypic analysis of 36 cases of pulmonary sclerosing pneumocytoma

Authors: 1YE Jiangang, 2YE Yuhong, 1DAI Zujian, 2WANG Pengcheng
1 Department of Chest Surgery, Fuzhou Pulmonary Hospital of Fujian Province, Fuzhou City Key Clinical Department, Fuzhou 350008, China
2 Department of Pathology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China

CorrespondingAuthor: YE Jiangang Email: yjgzmy@163.com

DOI: 10.3978/j.issn.2095-6959.2022.04.003

Foundation: This work was supported by the Fujian Provincial Health and Family Planning Training Project for Young and Middle-aged Key Talents, China (2019-ZQN-61).

Abstract

Objective: To explore the clinicopathological characteristics and immuophenotypes of pulmonary sclerosing pneumocytoma (PSP). Methods: The clinicopathological data of 36 PSP patients meeting the enrollment requirements were collected. The clinical manifestations, imaging and pathological characteristics, and immunophenotypes of the disease were analyzed. Results: PSP was most commonly seen in middle-aged females. Patients were typically asymptomatic. Imaging examination revealed that PSP presented with a solitary well-circumscribed mass. The key pathological features included circumscribed lesion, two types of tumor cells and four typical histological patterns. By immunohistochemistry, two types of tumor cells expressed TTF1, EMA and p-AKT. Additionally, cuboidal cells expressed CK, whereas round cells were positive for vimentin and usually positive for ER, PR. Neither of them expressed BRAF V600E. All the patients had no recurrence and metastasis during the follow-up. Conclusion: PSP lacks special clinical and imaging manifestations, but having diverse histological patterns. The pathological diagnosis depends on the key morphologic features including two types of tumor cells and four patterns and immunohistochemical staining. PSP clinically behaves in a benign fashion.
Keywords: pulmonary sclerosing pneumocytoma; clinicopathological characteristics; immunophenotype