1 河北省胸科医院口腔科，石家庄 050041
2 邯郸市第一医院口腔科，河北 邯郸 056002
目的：探讨奥美拉唑联合阿莫西林对牙周病患者牙周指数及肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)、白细胞介素-6(interleukin-6，IL-6)的影响。方法：选取2017年1月至2020年6月在河北省胸科医院就诊的牙周病患者194例，随机数表法分为对照组和试验组，每组97例。对照组选择常规牙周基础治疗，试验组在对照组基础上加用奥美拉唑联合阿莫西林治疗。对比两组疗效，治疗前后龈沟液炎症因子、T淋巴细胞水平、牙周指数以及药物不良反应情况。结果：治疗6周后，试验组治疗有效率(95.88%)明显高于对照组86.60%，差异有统计学意义(P<0.05)；试验组牙龈指数(gingival index，GI)、附着丧失(clinical attachment loss，CAL)、牙周袋深度(periodontal pocket depth，PD)、菌斑指数(plague index，PLI)均显著低于对照组，差异均有统计学意义(P<0.05)。试验组龈沟液中IL-6、TNF-α和CRP、CD3+、CD4+和CD4+/CD8+均显著低于对照组，CD8+水平显著高于对照组，差异均有统计学意义(P<0.05)。治疗期间，两组不良反应发生率比较差异无统计学意义(P>0.005)。结论：联合奥美拉唑和阿莫西林治疗的牙周病患者龈沟液中炎症因子、T淋巴细胞水平均显著降低，牙周指数得到显著改善，疗效优于常规牙周基础治疗。
Effects of omeprazole combined with amoxicillin on periodontal index and inflammatory factors TNF-α, IL-6 in patients with periodontal diseases
CorrespondingAuthor: XU Yunhai
This work was supported by the Geriatric Disease Prevention and Control Project of Hebei Provincial Department of Finance, China (361013).
Objective: To explore the effects of omeprazole combined with amoxicillin on periodontal index, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with periodontal diseases. Methods: A total of 194 patients with periodontal diseases treated in Hebei Chest Hospital between January 2017 and June 2020 were enrolled and divided into a control group (routine and basic periodontal treatment) and an experimental group (omeprazole combined with amoxicillin on basis of control group) by random number table method, 97 cases in each group. The curative effect, levels of inflammatory factors in gingival crevicular fluid (GCF), T lymphocytes, periodontal index and adverse drug reactions before and after treatment were compared between the two groups. Results: After 6 weeks of treatment, response rate of treatment in the experimental group was significantly higher than that in the control group (95.88% vs 86.60%), the difference was statistically significant (P<0.05). After 6 weeks of treatment, gingival index (GI), clinical attachment loss (CAL), periodontal pocket depth (PD) and plaque index (PLI) in the experimental group were significantly lower than those in the control group (P<0.05). The levels of IL-6, TNF-α, C-reactive protein (CRP), CD3+, CD4+ and CD4+/CD8+ in GCF of experimental group were significantly lower than those in control group, while CD8+ level was significantly higher than that in control group (all P<0.05). During treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P>0.005). Conclusion: The levels of inflammatory factors and T lymphocytes in GCF are significantly decreased in periodontal disease patients treated with omeprazole combined with amoxicillin, periodontal index is significantly improved, and the curative effect is better than that of routine and basic periodontal treatment.
periodontal disease; omeprazole; gingival crevicular fluid; amoxicillin; inflammatory factor