1 湖南师范大学附属第一医院，湖南省人民医院呼吸与危重症医学科，长沙 410000
|| 湖南省自然科学基金 (2015JJ2091)。
生长分化因子-15(growth differentiation factor-15，GDF-15)是转化生长因子-β(transforming growth factor-β，TGF-β)超家族的新成员，参与厌食、体重调节、炎症、上皮-间质转化、纤维化、癌症等多种病理生理过程，是一种重要的生长转化因子。肺癌是全球最常见的恶性肿瘤之一，具有较高的发病率和病死率，虽然新的化疗药物和分子靶向药物的研究应用及放疗技术有所发展，但是肺癌的预后仍较差，影响其预后的机制仍不清楚。本文从GDF-15及其特异性受体GFRAL、上游调控基因p53、GDF-15/PI3K/AKT、GDF-15/TGF-β/Smad相关信号传导通路、GDF-15如何参与调节肺癌的侵袭与转移以及GDF-15在肺癌放化疗中的作用和血清GDF-15升高在肺癌中常提示不良预后等几个方面对GDF-15与肺癌的关系进行阐述。
Research progress on the relationship between GDF-15 and lung cancer
CorrespondingAuthor: JIANG Gang
This work was supported by the Natural Science Foundation of Hunan Province, China (2015JJ2091).
Growth differentiation factor-15 (GDF-15) is a new member of the transforming growth factor-β (TGF-β) superfamily. It is involved in various pathophysiological processes such as anorexia, weight regulation, inflammation, epithelial-mesenchymal transformation, fibrosis, cancer, etc. It is an important growth transformation factor. Lung cancer is one of the most common malignant tumors in the world. It has a high morbidity and mortality rate. Despite the development of new chemotherapeutic drugs and molecular targeted drugs and radiotherapy technology, the prognosis of lung cancer is still poor, the mechanisms that influence its prognosis are not yet clear. In this paper, the relationship between GDF-15 and lung cancer was reviewed from the following aspects: GDF-15 and its specific receptor GFRAL, upstream regulatory gene p53, GDF-15/PI3K/AKT, GDF-15/TGF-β/SMAD signal transduction pathway, how GDF-15 plays a role in regulating the invasion and metastasis of lung cancer, the role of GDF-15 in lung cancer radiotherapy and chemotherapy, and the elevation of serum GDF-15 in lung cancer often suggest adverse prognosis.
growth differentiation factor-15; lung cancer; signal transduction mechanism