文章摘要

癌蛋白 YAP1 在宫颈癌中的研究现状与进展

作者: 1,2刘莉, 1,2顾科
1 江南大学附属医院放疗科,江苏 无锡 214000
2 江南大学无锡医学院, 江苏 无锡 214000
通讯: 顾科 Email: pilipolome@126.com
DOI: 10.3978/j.issn.2095-6959.2022.04.032
基金: 无锡市“太湖人才计划”医疗卫生高层次人才项目;江苏省卫生健康委员会妇幼健康科研项目(F202009);江苏省妇幼保健协会科研项目(FYX202016);无锡市卫生健康委员会科研项目(M202041)。

摘要

Yes相关蛋白1(Yes-associated protein 1,YAP1)是Hippo信号通路下游中的一个转录共激活因子,既 可参与细胞生长、发育及DNA修复,也可作为癌基因促进细胞异常增殖及恶性转化。YAP1表达与 宫颈癌临床分期和淋巴结转移关系密切,可作为宫颈癌预后的独立影响因素。本文对YAP1在宫颈 癌中的研究现状与进展作一综述,探讨YAP1作为治疗靶点在宫颈癌患者预后及治疗中的意义。
关键词: Yes相关蛋白1;Hippo信号通路;宫颈癌;靶向治疗

Oncoprotein YAP1 in cervical cancer: Current status and progress

Authors: 1,2LIU Li, 1,2GU Ke
1 Department of Radiotherapy, Jiangnan University Affiliated Hospital, Wuxi Jiangsu 214000, China
2 Wuxi School of Medicine, Jiangnan University, Wuxi Jiangsu 214000, China

CorrespondingAuthor: GU Ke Email: pilipolome@126.com

DOI: 10.3978/j.issn.2095-6959.2022.04.032

Foundation: This work was supported by Wuxi Taihu Lake Talent Plan, Supports for Leading Talents in Medical and Health Profession; Maternal and Child Health Research Project of Jiangsu Provincial Health Commission (F202009); Scientific Research Project of Jiangsu Maternal and Child Health Care Association (FYX202016); Scientific Research Project of Wuxi Municipal Health Committee (M202041), China.

Abstract

Yes-associated protein 1 (YAP1) is a transcriptional co-activator in the downstream of the Hippo signaling pathway. It can not only participate in cell growth, development, and DNA repair, but also act as an oncogene to promote abnormal cell proliferation and malignant transformation. It has been demonstrated that the expression of YAP1 is closely related to the clinical stage and lymph node metastasis of cervical carcinoma, and may be an independent prognostic factor. This article examines the current status and progress of YAP1 in cervical cancer, and discusses the significance of YAP1 as a therapeutic target in the prognosis and treatment of cervical cancer.
Keywords: Yes-associated protein 1; Hippo pathway; cervical cancer; targeted therapy