文章摘要

可调控活性氧的纳米声敏剂在声动力疗法的应用进展

作者: 1卢璐, 2张坤, 1徐晓红
1 广东医科大学第一临床医学院,广东 湛江 524000
2 同济大学附属第十人民医院超声医学科,上海 200072
通讯: 徐晓红 Email: 13828297586@139.com
DOI: 10.3978/j.issn.2095-6959.2022.04.036
基金: 国家自然科学基金(81771836,81501473);上海市科学技术委员会青年科技启明星项目(A类)(19QA1406800)。

摘要

声动力疗法(sonodynamic therapy,SDT)是一种有潜力的治疗方法,具有微创、安全、疗效好等优 点。超声波(ultrasound,US)可以聚焦到肿瘤区域激活声敏剂,主要通过生成各种活性氧(reactive oxygen species,ROS)物质发挥抗肿瘤作用。SDT疗效主要取决于肿瘤细胞内ROS的浓度。纳米声 敏剂具有体积小、尺寸可调、稳定性高、载体容量高的优点。因此如何开发与应用纳米声敏剂调 节ROS产量,使肿瘤抑制效率达到最大是当前研究的热点之一。本文将总结纳米声敏剂促进ROS 生成和减少ROS消耗这2种调节策略的研究现状,旨在探究其向临床转化的潜力。
关键词: 声动力疗法;活性氧;纳米声敏剂;肿瘤

Advances in the application of nanosonosensitizers for modulating reactive oxygen species in sonodynamic therapy

Authors: 1LU Lu, 2ZHANG Kun, 1XU Xiaohong
1 First Clinical Medical College, Guangdong Medical University, Zhanjiang Guangdong 524000, China
2 Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, China

CorrespondingAuthor: XU Xiaohong Email: 13828297586@139.com

DOI: 10.3978/j.issn.2095-6959.2022.04.036

Foundation: This work was supported by the National Natural Science Foundation (81771836, 81501473) and the Shanghai Science and Technology Committee Rising-Star Program (A type) (19QA1406800), China.

Abstract

Sonodynamic therapy (SDT) is a promising treatment method with the advantages of minimally invasive, safety and efficacy. Ultrasound (US) can be focused to the tumor area to activate sonosensitizers, which enhances anti-tumor effects mainly through the generation of various reactive oxygen species (ROS). The level of ROS in tumor cells is closely related to the effect of SDT. Nanosonosensitizer has the advantages of small size, adjustable size, high stability and high carrier capacity. So how to develop and apply nanosonosensitizers to modulate the production of ROS to maximize the efficiency of tumor suppression is one of the hot spots of current research. This paper summarizes the current status of research on two modulation strategies including the promotion of ROS production and the reduction of ROS consumption by nanosonosensitizers, with the aim of exploring their potential for clinical translation.
Keywords: sonodynamic therapy; reactive oxygen species; nanosonosensitizers; tumour