文章摘要

新生儿维生素D水平与肺炎炎症指标水平的相关性

作者: 1俞海飞, 1刘利英
1 苏州大学附属第二医院儿科,江苏 苏州 215151
通讯: 刘利英 Email: xeklly@163.com
DOI: 10.3978/j.issn.2095-6959.2022.04.007

摘要

目的:分析新生儿维生素D水平与肺炎炎症指标水平的相关性,旨在为临床新生儿肺炎的预防和病情评估提供依据。方法:选择2020年7月至2021年7月苏州大学附属第二医院收治的150例新生儿肺炎患儿为观察组,再选择同期健康体检的150例新生儿为对照组。将观察组分为观察A组、观察B组,观察A组行拉氧头孢治疗,观察B组行拉氧头孢联合维生素D治疗。对比对照组、观察组治疗前维生素D水平、炎症因子水平与观察组治疗前后维生素D水平、炎症因子水平,分析新生儿肺炎患儿治疗前后维生素D水平与炎症因子水平的相关性。结果:观察组治疗前维生素D水平低于对照组,C反应蛋白、降钙素原与白细胞水平高于对照组(P<0.05);观察A组、观察B组治疗后维生素D水平高于治疗前,C反应蛋白、降钙素原与白细胞水平低于治疗前(P<0.05);且观察B组治疗后维生素D水平高于观察A组,C反应蛋白、降钙素原与白细胞水平低于观察A组(P<0.05);经多因素回归分析,新生儿肺炎患儿维生素D水平与C反应蛋白、降钙素原与白细胞水平呈现明显负相关(P<0.05)。结论:新生儿肺炎患儿维生素D水平与C反应蛋白、降钙素原与白细胞水平呈现明显负相关,给予维生素D进行治疗可明显降低患儿炎症因子水平。
关键词: 新生儿;维生素D;肺炎;炎症指标;相关性

Correlation of neonatal vitamin D level and inflammation index level of pneumonia

Authors: 1YU Haifei, 1LIU Liying
1 Department of Pediatrics, Second Affiliated Hospital of Soochow University, Suzhou Jiangsu 215151, China

CorrespondingAuthor: LIU Liying Email: xeklly@163.com

DOI: 10.3978/j.issn.2095-6959.2022.04.007

Abstract

Objective: To analyze the correlation between neonatal vitamin D level and inflammatory index levels of pneumonia, in order to provide basis for clinical prevention and condition evaluation of neonatal pneumonia. Methods: A total of 150 cases of neonatal pneumonia admitted to our hospital from July 2020 to July 2021 were selected as the observation group, and 150 newborns who came to our hospital for physical examination during the same period were selected as the control group. The observation group was divided into observation group A and observation group B. Observation group A was treated with moxalactam, and observation group B was treated with moxalactam combined with vitamin D. The vitamin D levels and inflammatory factor levels before treatment in the control group and the observation group were compared with those in the observation group before and after treatment, and the correlation between vitamin D levels and inflammatory factor levels before and after treatment in neonatal pneumonia children was analyzed. Results: The vitamin D levels of the observation group before treatment were lower than those of the control group, and the levels of C-reactive protein, procalcitonin and white blood cells were higher than those of the control group (P<0.05); the vitamin D levels of observation group A and observation group B after treatment were higher than those before treatment; C-reactive protein, procalcitonin, and white blood cell levels were lower than before treatment (P<0.05); and the level of vitamin D after treatment in the observation group B was higher than that in the observation group A, and the levels of C-reactive protein, procalcitonin and white blood cells were lower than those in observation group A (P<0.05); after multivariate regression analysis, vitamin D levels in children with neonatal pneumonia were significantly negatively correlated with C-reactive protein, procalcitonin, and white blood cell levels (P<0.05). Conclusion: The level of vitamin D in children with neonatal pneumonia is significantly negatively correlated with the levels of C-reactive protein, procalcitonin, and white blood cells. Vitamin D treatment can significantly reduce the levels of inflammatory factors in children.
Keywords: newborn; vitamin D; pneumonia; inflammatory indicators; correlation