1 徐州市第一人民医院(徐州医科大学附属徐州市立医院)麻醉科，江苏 徐州 221116
2 徐州市矿务局集团总医院麻醉科，江苏 徐州 221000
Effect of pretreatment with esmketamine hydrochloride on postoperative recovery of strabismus in children under general anesthesia
CorrespondingAuthor: MA Xingdui Email: firstname.lastname@example.org
Foundation: This work was supported by the Development Fund of Affiliated Hospital of Xuzhou Medical University (Fund for Excellent Talents), China (XYFY2020003).
Objective: To investigate the effect of esmketamine hydrochloride pretreatment on postoperative recover of strabismus surgery in children. Methods: Ninety-six children who planned to receive strabismus correction under general anesthesia were selected and randomly divided into an experimental group and a control group by blind selection, each group with 48 cases. After anesthesia induction, the corresponding type of laryngeal mask was inserted. After the induction, the experimental group was given esmketamine hydrochloride 0.5 mg/kg (0.02 mL/kg), and the control group was given an equal volume of sodium chloride injection. The incidence of agitation, postoperative pain score, nausea, vomiting and other adverse reactions were recorded and compared between the 2 groups. Results: The incidence of emergence agitation was 25% (12/48) in the control group and 8.3% (4/48) in the experimental group, and the difference was statistically significant (P<0.05). Compared with the control group, the pain scores of the experimental group were lower at 5, 10 and 30 min after waking up, and the difference was statistically significant (all P<0.05). Compared with the control group, there was no significant difference in operation time, extubation time, and post-anesthesia care unit (PACU) residence time of the experimental group (all P>0.05). Compared with the control group, the heart rate and respiratory rate of the children in the experimental group were lower than those in the control group at 20 and 30 min, and the difference was statistically significant (all P<0.05). There was no significant difference in blood oxygen saturation between the 2 groups (P>0.05). There was no statistically significant difference in the incidence of adverse reactions such as nausea, vomiting, skin pruritus, chills, and respiratory depression between the 2 groups of patients during the recovery period (all P>0.05). Conclusion: Esmketamine hydrochloride pretreatment can reduce the pain degree and postoperative agitation in children with strabismus surgery, and does not increase the incidence of adverse reactions, which is worthy of further promotion.