1 兰州大学第一临床医学院，兰州 730000
2 兰州大学第一医院超声科，兰州 730000
3 兰州大学第一医院乳腺病科，兰州 730000
Diagnostic value of conventional ultrasound combined with ABVS and diffuse optical tomography in breast cancer
CorrespondingAuthor: MA Sumei Email: firstname.lastname@example.org
Foundation: This work was supported by the Natural Science Foundation of Gansu Province, China (1606RJZA118).
Objective: To evaluate the value of conventional ultrasound, automatic breast volume scanner (ABVS), diffuse optical tomography (DOT) and their combination for the diagnosis of breast cancer. Methods: In a prospective study, 86 breast lesions in 72 patients were examined by conventional ultrasound, ABVS and DOT. The breast imaging reporting and date system (BI-RADS) classification of conventional ultrasound and ABVS was performed, and the synthetic diagnostic index reporting and date system (SDI-RADS) classification of DOT was obtained. Taking postoperative pathological results as the “gold standard”, the receiver operating characteristic (ROC) curves of conventional ultrasonography, ABVS, DOT alone and their combination for the diagnosis of benign and malignant breast lesions were drawn, and the diagnostic efficiency was analyzed. To analyze the difference of the area under the ROC curve (AUC) between benign and malignant breast lesions diagnosed by conventional ultrasound, ABVS, DOT and the combination. Results: The cut-off value of benign and malignant breast lesions diagnosed by ABVS and conventional ultrasound was BI-RADS 4B and DOT was SDI-RADS 4B. The AUC of conventional ultrasound, ABVS, DOT and their combined diagnosis were 0.768, 0.893, 0.902, and 0.780, respectively. There were statistically significant differences in AUC between ABVS and conventional ultrasound, ABVS and combined diagnosis, DOT and conventional ultrasound, DOT and combined diagnosis (P=0.0001, 0.0052, 0.0053, 0.0010, respectively). There was no significant difference in AUC between conventional ultrasound and combined diagnosis, ABVS and DOT (P=0.7695, 0.8471, respectively). The sensitivity of combined diagnosis was 93.88%, which was higher than conventional ultrasound (73.47%), ABVS (79.59%), and DOT (89.80%) (all P<0.0001). Conclusion: The new ultrasound techniques ABVS and DOT are of high value for the diagnosis of benign and malignant breast lesions. Combined diagnosis cannot improve the diagnostic accuracy and reduce the misdiagnosis rate of breast cancer, but can improve the detection rate.