1 秦皇岛市工人医院麻醉科，河北 秦皇岛 066200
2 深州市医院麻醉科，河北 衡水 053000
Effect of intraoperative continuous infusion of dexmedetomidine on postoperative sleep quality in patients underwent laparoscopic hysteromyomectomy
CorrespondingAuthor: SHI Shaokai Email: email@example.com
Foundation: This work was supported by the Qinhuangdao Science and Technology Research and Development Program Project, China (201902A208).
Objective: To investigate the effect of intraoperative continuous infusion of dexmedetomidine on postoperative sleep quality in patients undergoing laparoscopic hysteromyomectomy. Methods: A total of 150 patients undergoing laparoscopic hysteromyomectomy in Qinhuangdao Workers’ Hospital from June 2019 to May 2021 were selected and randomly divided into control group (n=75) and observation group (n=75). The observation group was continuously pumped with dexmedetomidine 0.5 μg/(kg·h) after anesthesia induction, while the control group was pumped with normal saline 0.125 mL/(kg·h) until the end of operation. Both groups received patient controlled intravenous analgesia (PCIA) after operation. The sleep quality of the 2 groups was evaluated by polysomnography and Pittsburgh Sleep Quality Index (PSQI) score before operation and 1 d and 2 d after operation. Numerical sedation scale (NSS) was used to evaluate the sedative effect at 6 h, 24 h and 48 h after operation. The postoperative sufentanil dosage and remedial analgesia rate were recorded in the 2 groups. Results: At 1 d and 2 d after operation, the sleep efficiency index (SEI) in the observation group was significantly higher than that in the control group (P<0.05), and the arousal index (AI) and PSQI score were significantly lower than those in the control group (P<0.05). The incidence of sleep disorder in the observation group was 18.67%, which was significantly lower than 34.67% in the control group, and the difference was statistically significant (P<0.05). Compared with the control group, the NSS scores at 6 h and 24 h after operation in the observation group were significantly increased (P<0.05). Compared with the control group, the amount of sufentanil and the rate of remedial analgesia in the observation group were decreased, and the difference was statistically significant (P<0.05). Conclusion: Continuous intraoperative infusion of dexmedetomidine can improve the postoperative sleep quality of patients undergoing laparoscopic hysteromyomectomy and prevent the occurrence of sleep disorders.