1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150000
Research progress in the pathogenesis of venous thromboembolism in idiopathic membranous nephropathy
CorrespondingAuthor: XIE Rujuan Email: email@example.com
Foundation: This work was supported by Heilongjiang Provincial Natural Science Foundation for Excellent Young Scholars, China (YQ2019H019).
Venous thromboembolism (VTE) is one of the common complications of idiopathic membranous nephropathy (IMN) and is associated with mortality. Traditionally, the mechanism of VTE mainly includes the imbalance of procoagulant, anticoagulant, and fibrinolytic systems caused by proteinuria and compensatory synthesis of the liver. However, this can’t explain the mechanism of high VTE risk in IMN patients, so it is urgent to explore its unique formation mechanism. Inflammation is involved in the development of IMN, and activation of the inflammatory system affects the Virchow’s triad: endothelial dysfunction and hypercoagulability. By summarizing the epidemiological characteristics and possible pathophysiological mechanisms of VTE occurrence in IMN patients under the framework of the Virchow’s triad, it is possible to provide future directions for the pathogenesis of VTE and more therapeutic targets and strategies for early prevention and treatment.